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利用生信分析探索基因ASPN在PCa诊断与治疗中的应用

胡余攀, 王志刚

摘要

目的：通过生信技术寻找前列腺癌的关键基因，为临床诊断和治疗提供支持。方法：从基因表达数据库筛选数据，使用在线工具处理并通过韦恩图筛选高表达基因。利用David 6.8进行功能富集和通路分析，构建蛋白互作网络，并结合可视化工具进行处理。最后，借助癌症基因组图谱数据评估ASPN在前列腺癌病程中的作用。结果：筛选出的中枢基因中包含2个促癌基因和多个抑癌基因。GO功能和KEGG分析显示，这些基因在前列腺癌中作用复杂，对不同病程影响各异。cBioPortal分析表明，促癌基因高表达与患者较差的临床预后相关。结论：ASPN在前列腺癌中具有重要临床意义，对病程影响显著，其发现为前列腺癌的诊断和治疗提供了新方向。

关键词

生信分析；前列腺癌；ASPN

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参考

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