β- 谷甾醇在防治消化道肿瘤中的机制研究进展
摘要
的营养素，具有抗炎、抗氧化、抗动脉粥样硬化等生物活性，并且近年来在消化道肿瘤如胃癌、结直肠癌、肝癌、胰腺癌
中表现出明显的抗肿瘤作用。本文通过总结 β- 谷甾醇在消化道肿瘤中的分子机制，为消化道肿瘤的诊治提供更多的选择。
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[1]SUNG H, FERLAY J, SIEGEL R L, et al. Global Cancer
Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality
Worldwide for 36 Cancers in 185 Countries [J]. CA Cancer J Clin,
2021, 71(3): 209-249.
[2]WEI C, DA C H, WEN Y Y, et al. Changing profiles of
cancer burden worldwide and in China:a secondary analysis of the
global cancer statistics 2020 [J]. Chinese Medical Journal, 2021,
134(7).
[3]MOREAU R A, WHITAKER B D, HICKS K B.
Phytosterols, phytostanols, and their conjugates in foods: structural
diversity, quantitative analysis, and health-promoting uses [J].
Progress in lipid research, 2002, 41(6): 457-500.
[4]BABU S, JAYARAMAN S. An update on β-sitosterol:
A potential herbal nutraceutical for diabetic management
[J]. Biomedicine & pharmacotherapy = Biomedecine &
pharmacotherapie, 2020, 131: 110702.
[5]LIN F, XU L, HUANG M, et al. β-Sitosterol Protects
against Myocardial Ischemia/Reperfusion Injury via Targeting
PPARγ/NF-κB Signalling [J]. Evidence-based complementary
and alternative medicine : eCAM, 2020, 2020: 2679409.
[6]TADA H, NOHARA A, INAZU A, et al. Sitosterolemia,
Hypercholesterolemia, and Coronary Artery Disease [J]. Journal of
atherosclerosis and thrombosis, 2018, 25(9): 783-789.
[7]PANIAGUA-PéREZ R, FLORES-MONDRAGóN
G, REYES-LEGORRETA C, et al. EVALUATION OF THE
ANTI-INFLAMMATORY CAPACITY OF BETA-SITOSTEROL
IN RODENT ASSAYS [J]. African journal of traditional,
complementary, and alternative medicines : AJTCAM, 2017,
14(1): 123-130.
[8]NA J, EFFERTH T. Insights into apoptotic proteins in
chemotherapy: quantification techniques and informing therapy
choice [J]. Expert review of proteomics, 2018, 15(5): 413-429.
[9]GOTTESMAN M M. Mechanisms of cancer drug resistance
[J]. Annual review of medicine, 2002, 53: 615-627.
[ 1 0 ] K H O O G A R R , K I M B C , M O R R I S J , e t a l .
Chemoprevention in gastrointestinal physiology and disease.
Targeting the progression of cancer with natural products: a focus
on gastrointestinal cancer [J]. American journal of physiology
Gastrointestinal and liver physiology, 2016, 310(9): G629-644.
[11]SHIN E J, CHOI H K, SUNG M J, et al. Anti-tumour
effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90
axis in AGS human gastric adenocarcinoma cells and xenograft
mouse models [J]. Biochemical pharmacology, 2018, 152: 60-70.
[12]ZHAO Y, CHANG S K, QU G, et al. Beta-sitosterol
inhibits cell growth and induces apoptosis in SGC-7901 human
stomach cancer cells [J]. Journal of agricultural and food
chemistry, 2009, 57(12): 5211-5218.
[13] 王娟 , 刘军权 , 陈复兴 .β- 谷甾醇对人共刺激细胞
杀伤胃癌 SGC-7901 细胞的影响及其机制的探讨 [J]. 免疫学
杂志 ,2014,30(07):578-584.
[14]KAWK H W, NAM G H, KIM M J, et al. Scaphium
affine Ethanol Extract Induces Anoikis by Regulating the EGFR/
Akt Pathway in HCT116 Colorectal Cancer Cells [J]. Frontiers in
oncology, 2021, 11: 621346.
[ 1 5 ] S A L A M A T U L L A H A M , S U B A S H - B A B U P ,
NASSRALLAH A, et al. Cyclotrisiloxan and β-Sitosterol rich
Cassia alata (L.) flower inhibit HT-115 human colon cancer cell
growth via mitochondrial dependent apoptotic stimulation [J].
Saudi journal of biological sciences, 2021, 28(10): 6009-6016.
[16]PERILLO B, DI DONATO M, PEZONE A, et al. ROS
in cancer therapy: the bright side of the moon [J]. Experimental &
molecular medicine, 2020, 52(2): 192-203.
[17]GU S, LIU F, XIE X, et al. β-Sitosterol blocks the
LEF-1-mediated Wnt/β-catenin pathway to inhibit proliferation
of human colon cancer cells [J]. Cell Signal, 2023, 104: 110585.
[18]WANG Z, ZHAN Y, XU J, et al. β-Sitosterol Reverses
Multidrug Resistance via BCRP Suppression by Inhibiting the
p53-MDM2 Interaction in Colorectal Cancer [J]. Journal of
agricultural and food chemistry, 2020, 68(12): 3850-3858.
[19]PEOPLE N H C O T, #39, CHINA S R O. 原 发 性 肝
癌诊疗指南 (2022 年版 ) [J]. 肿瘤综合治疗电子杂志 , 2022,
8(02): 16-53.
[20]SUH J K, LEE J, LEE J H, et al. Risk factors for
developing liver cancer in people with and without liver disease [J].
PloS one, 2018, 13(10): e0206374.
[21]MOHAMMAD R M, MUQBIL I, LOWE L, et al. Broad
targeting of resistance to apoptosis in cancer [J]. Seminars in
cancer biology, 2015, 35 Suppl(0): S78-s103.
[22]LI Q, JIANG C, ZU Y, et al. SFE-CO2 extract from
Typhonium giganteum Engl. tubers, induces apoptosis in human
hepatoma SMMC-7721 cells involvement of a ROS-mediated
mitochondrial pathway [J]. Molecules (Basel, Switzerland), 2011,
16(10): 8228-8242.
[23]DITTY M J, EZHILARASAN D. β-sitosterol
induces reactive oxygen species-mediated apoptosis in human
hepatocellular carcinoma cell line [J]. Avicenna J Phytomed, 2021,
11(6): 541-550.
[24]YUAN Y G, ZHANG S, HWANG J Y, et al. Silver
Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential
of Camptothecin in Human Cervical Cancer Cells [J]. Oxidative
medicine and cellular longevity, 2018, 2018: 6121328.
[25]RAJ R K, D E, S R. β-Sitosterol-assisted silver
nanoparticles activates Nrf2 and triggers mitochondrial apoptosis
via oxidative stress in human hepatocellular cancer cell line [J].
Journal of biomedical materials research Part A, 2020, 108(9):
1899-1908.
[26] 张 忠 泉 , 邢 煜 君 , 胡 国 强 , 等 .β- 谷 甾 醇 诱
导 人 肝 癌 HepG2 细 胞 凋 亡 机 制 研 究 [J]. 中 国 中 药 杂
志 ,2011,36(15):2145-2148.
[27]WANG H, WANG Z, ZHANG Z, et al. β-Sitosterol
as a Promising Anticancer Agent for Chemoprevention and
Chemotherapy: Mechanisms of Action and Future Prospects [J].
Advances in nutrition (Bethesda, Md), 2023, 14(5): 1085-1110.
[28] 李 庆 勇 , 姜 春 菲 , 张 黎 , 等 .β- 谷 甾 醇、 豆
甾 醇 诱 导 人 肝 癌 细 胞 SMMC-7721 凋 亡 [J]. 时 珍 国 医 国
药 ,2012,23(05):1173-1175.
[29] 王 凯 , 李 卫 , 李 志 芳 , 等 .β- 谷 甾 醇 靶 向
CDC25B 抑制肝癌细胞增殖 [J]. 中山大学学报 ( 医学科学
版 ),2022,43(04):675-684.
[30] 林明珠 , 赵岩 , 蔡恩博 , 等 .β- 谷甾醇对 H_(22) 荷
瘤小鼠体内抗肿瘤作用 [J]. 中国公共卫生 ,2017,33(12):1797-
1800.
[31] 陈浩 , 陈文滨 , 郑建华 . 半枝莲 β- 谷甾醇抗肝肿
瘤机制的研究 [J]. 今日药学 ,2017,27(06):380-381+384.
[32]XIA C, DONG X, LI H, et al. Cancer statistics in China
and United States, 2022: profiles, trends, and determinants [J].
Chin Med J (Engl), 2022, 135(5): 584-590.
[33]PU C Y, LAN V M, LAN C F, et al. The determinants
of traditional Chinese medicine and acupuncture utilization for
cancer patients with simultaneous conventional treatment [J].
European journal of cancer care, 2008, 17(4): 340-349.
[34] 程静 , 刘军权 , 陈复兴 , 等 . β- 谷甾醇对人自然杀
伤细胞杀伤胰腺癌 SW-1990 细胞的影响 [J]. 检验医学与临
床 , 2012, 9(24): 3078-3080+3082.
[35]CAO Z Q, WANG X X, LU L, et al. Corrigendum:
β-Sitosterol and Gemcitabine Exhibit Synergistic AntiPancreatic Cancer Activity by Modulating Apoptosis and
Inhibiting Epithelial-Mesenchymal Transition by Deactivating
Akt/GSK-3β Signaling [J]. Frontiers in pharmacology, 2020, 11:
565535.
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