开放期刊系统

外泌体在慢性疼痛中的研究进展

徐 芒, 蒋 月, 黄 佳欣

摘要

慢性疼痛,大多是由外周或中心的身体感觉神经遭受破坏或病变的后果,在临床上最常用的慢性痛种类包括痛性多发性神经系统病、神经病理性疼痛和癌性痛、带状疱疹后神经痛、三叉神经痛和中风后痛等。外泌体是一种细胞外囊泡,转运的多种生物活性物质已经成为细胞功能的重要调节因子,同时这些货物在各种条件下储存稳定,这表明多种外泌体中的内容物可以作为一种稳定的生物标志物,在疾病诊断、治疗和预后预测发挥巨大的潜力。本文旨在就国内外对于慢性疼痛情况下外泌体的研究现状进行综述。

关键词

慢性疼痛;细胞外囊泡;外泌体;生物标志物

全文:

PDF

参考

[1]COHEN S P,VASE L,HOOTEN W M. Chronic pain:an update on burden,best practices,and new advances [J]. Lancet(London,

England),2021,397(10289):2082-97.

[2]DUTTA D,KHAN N,WU J,et al. Extracellular Vesicles as an Emerging Frontier in Spinal Cord Injury Pathobiology and Therapy [J].

Trends in neurosciences,2021,44(6):492-506.

[3]RAMIREZ S H,ANDREWS A M,PAUL D,et al. Extracellular vesicles:mediators and biomarkers of pathology along CNS barriers

[J]. Fluids and barriers of the CNS,2018,15(1):19.

[4]SHOJAEI S,HASHEMI S M,GHANBARIAN H,et al. Effect of mesenchymal stem cells-derived exosomes on tumor

microenvironment:Tumor progression versus tumor suppression [J]. Journal of cellular physiology,2019,234(4):3394-409.

[5]GURUNATHAN S,KANG M H,JEYARAJ M,et al. Review of the Isolation,Characterization,Biological Function,and Multifarious

Therapeutic Approaches of Exosomes [J]. Cells,2019,8(4).

[6]YU X,ABDUL M,FAN B Q,et al. The release of exosomes in the medial prefrontal cortex and nucleus accumbens brain regions of

chronic constriction injury(CCI)model mice could elevate the pain sensation [J]. Neuroscience letters,2020,723:134774.

[7]BRUEHL S. Complex regional pain syndrome [J]. BMJ(Clinical research ed),2015,351:h2730.

[8]SIMEOLI R,MONTAGUE K,JONES H R,et al. Exosomal cargo including microRNA regulates sensory neuron to macrophage

communication after nerve trauma [J]. Nature communications,2017,8(1):1778.

[9]THéRY C,WITWER K W,AIKAWA E,et al. Minimal information for studies of extracellular vesicles 2018(MISEV2018):a

position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines [J]. Journal of

extracellular vesicles,2018,7(1):1535750.

[10]CIREGIA F,URBANI A,PALMISANO G. Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases [J]. Frontiers in

molecular neuroscience,2017,10:276.

[11]STOORVOGEL W. Functional transfer of microRNA by exosomes [J]. Blood,2012,119(3):646-8.

[12]RAMANATHAN S,DOUGLAS S R,ALEXANDER G M,et al. Exosome microRNA signatures in patients with complex regional

pain syndrome undergoing plasma exchange [J]. Journal of translational medicine,2019,17(1):81.

[13]BERNARDO B C,OOI J Y,LIN R C,et al. miRNA therapeutics:a new class of drugs with potential therapeutic applications in the

heart [J]. Future medicinal chemistry,2015,7(13):1771-92.

[14]BRANSCOME H,PAUL S,YIN D,et al. Use of Stem Cell Extracellular Vesicles as a "Holistic" Approach to CNS Repair [J].

Frontiers in cell and developmental biology,2020,8:455.

[15]JEAN-TOUSSAINT R,TIAN Y,CHAUDHURI A D,et al. Proteome characterization of small extracellular vesicles from spared

nerve injury model of neuropathic pain [J]. Journal of proteomics,2020,211:103540.

[16]CALVO M,DAWES J M,BENNETT D L. The role of the immune system in the generation of neuropathic pain [J]. The Lancet

Neurology,2012,11(7):629-42.

[17]YATES A G,ANTHONY D C,RUITENBERG M J,et al. Systemic Immune Response to Traumatic CNS Injuries-Are ExtracellularVesicles the Missing Link? [J]. Frontiers in immunology,2019,10:2723.

[18]DATTA CHAUDHURI A,DASGHEYB R M,DEVINE L R,et al. Stimulus-dependent modifications in astrocyte-derived

extracellular vesicle cargo regulate neuronal excitability [J]. Glia,2020,68(1):128-44.

[19]GALLO A,TANDON M,ALEVIZOS I,et al. The majority of microRNAs detectable in serum and saliva is concentrated in exosomes

[J]. PloS one,2012,7(3):e30679.

[20]AUSTIN P J,MOALEM-TAYLOR G. The neuro-immune balance in neuropathic pain:involvement of inflammatory immune cells,

immune-like glial cells and cytokines [J]. Journal of neuroimmunology,2010,229(1-2):26-50.

[21]SHI M,SHENG L,STEWART T,et al. New windows into the brain:Central nervous system-derived extracellular vesicles in blood

[J]. Progress in neurobiology,2019,175:96-106.

[22]PRADA I,GABRIELLI M,TUROLA E,et al. Glia-to-neuron transfer of miRNAs via extracellular vesicles:a new mechanism

underlying inflammation-induced synaptic alterations [J]. Acta neuropathologica,2018,135(4):529-50.

[23]BäCKRYD E,GHAFOURI B,LARSSON B,et al. Do low levels of beta-endorphin in the cerebrospinal fluid indicate defective

top-down inhibition in patients with chronic neuropathic pain? A cross-sectional,comparative study [J]. Pain medicine(Malden,Mass),

2014,15(1):111-9.

[24]BUENO M J,PéREZ DE CASTRO I,MALUMBRES M. Control of cell proliferation pathways by microRNAs [J]. Cell cycle

(Georgetown,Tex),2008,7(20):3143-8.

[25]ZHU W,SUN L,ZHAO P,et al. Macrophage migration inhibitory factor facilitates the therapeutic efficacy of mesenchymal stem cells

derived exosomes in acute myocardial infarction through upregulating miR-133a-3p [J]. Journal of nanobiotechnology,2021,19(1):61.

[26]RUFINO-RAMOS D,ALBUQUERQUE P R,CARMONA V,et al. Extracellular vesicles:Novel promising delivery systems for

therapy of brain diseases [J]. Journal of controlled release:official journal of the Controlled Release Society,2017,262:247-58.

[27]CHEN C C,LIU L,MA F,et al. Elucidation of Exosome Migration across the Blood-Brain Barrier Model In Vitro [J]. Cellular and

molecular bioengineering,2016,9(4):509-29.

[28]REGEV-RUDZKI N,WILSON D W,CARVALHO T G,et al. Cell-cell communication between malaria-infected red blood cells via

exosome-like vesicles [J]. Cell,2013,153(5):1120-33.

[29]DICKENS A M,TOVAR Y R L B,YOO S W,et al. Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response

to inflammatory brain lesions [J]. Science signaling,2017,10(473).

[30]SAEEDI S,ISRAEL S,NAGY C,et al. The emerging role of exosomes in mental disorders [J]. Translational psychiatry,2019,9

(1):122.

[31]TOFIñO-VIAN M,GUILLéN M I,PéREZ DEL CAZ M D,et al. Microvesicles from Human Adipose Tissue-Derived

Mesenchymal Stem Cells as a New Protective Strategy in Osteoarthritic Chondrocytes [J]. Cellular physiology and biochemistry:

international journal of experimental cellular physiology,biochemistry,and pharmacology,2018,47(1):11-25.

[32]KUMAR A,STOICA B A,LOANE D J,et al. Microglial-derived microparticles mediate neuroinflammation after traumatic brain

injury [J]. Journal of neuroinflammation,2017,14(1):47.

[33]CHEN O,DONNELLY C R,JI R R. Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory

neurons [J]. Current opinion in neurobiology,2020,62:17-25.

[34]CHAUDHURI A D,DASTGHEYB R M,YOO S W,et al. TNFα and IL-1β modify the miRNA cargo of astrocyte shed

extracellular vesicles to regulate neurotrophic signaling in neurons [J]. Cell death & disease,2018,9(3):363.

[35]GONCALVES M B,MALMQVIST T,CLARKE E,et al. Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons

and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration [J]. The Journal of

neuroscience:the official journal of the Society for Neuroscience,2015,35(47):15731-45.

[36]SEKINE Y,LINDBORG J A,STRITTMATTER S M. A proteolytic C-terminal fragment of Nogo-A(reticulon-4A)is released in

exosomes and potently inhibits axon regeneration [J]. The Journal of biological chemistry,2020,295(8):2175-83.

[37]MILLIGAN E D,WATKINS L R. Pathological and protective roles of glia in chronic pain [J]. Nature reviews Neuroscience,2009,

10(1):23-36.

[38]TKACH M,THéRY C. Communication by Extracellular Vesicles:Where We Are and Where We Need to Go [J]. Cell,2016,164

(6):1226-32.

[39]CHANG L L,WANG H C,TSENG K Y,et al. Upregulation of miR-133a-3p in the Sciatic Nerve Contributes to Neuropathic Pain

Development [J]. Molecular neurobiology,2020,57(9):3931-42.

[40]HUANG L,WANG L. Upregulation of miR-183 represses neuropathic pain through inhibiton of MAP3K4 in CCI rat models [J].

Journal of cellular physiology,2020,235(4):3815-22.

作者简介:徐芒,硕士研究生,助教,研究方向:基础医学;

蒋月,大学本科,研究方向:基础医学;

黄佳欣,大学本科,研究方向:基础医学。


(0 摘要 Views, 1 PDF Downloads)

Refbacks

  • 当前没有refback。