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洛拉替尼在新型 KIF5B-ALK 融合癌激酶肺腺癌治疗策略中的 应用 1 例

梁 欣怡, 朴 红梅

摘要

本文报道1例81岁女性患者,因间断咳嗽咳痰伴呼吸困难,行肺部CT发现右肺门团块状高密度影,右侧大量胸腔积液伴肺不张,进一步检查入院,入院后肺组织活检病理示非小细胞癌,结合形态及免疫组化结果考虑腺癌,基因检测:EGFR exon21突变,NOTCH1 exon34突变,TP53exon5突变,KIF5B-ALK intron15-exon19突变,口服三代靶向药洛拉替尼3个月后复查,患者头部转移灶部分消失,部分较前缓解。介绍了患者的临床和影像学表现,病理学特点以及三代药物的选择,以加深对这类罕见突变位点的认识。

关键词

KIF5B-ALK融合基因,肺癌,ALK抑制剂,基因突变,融合,表达

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参考

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