肺内去分化脂肪肉瘤一例
摘要
脂肪细胞肿瘤细胞成分共存。去分化（DD） 和高分化（WD）成分都表现出 MDM2 扩增，原发于肺的病例极为罕见，多
数为转移性或胸膜 / 纵隔原发灶的直接侵犯。发病机制可能与染色体 12q13-15 区域的基因扩增（如 MDM2、CDK4）相关，
MDM2 过表达是诊断标志之一。本病例为一名 68 岁男性患者，体检发现肺部阴影遂来我院住院检查，CT 报告为右肺下叶
占位性病变，经胸外科手术切除，病理诊断为肺内去分化脂肪肉瘤。
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