子宫内膜异位症与妇科肿瘤的关联研究 - 综述
摘要
子宫内膜样癌是与恶性子宫内膜异位症相关的两种最常见的组织学亚型 [1]。这一发现引发了临床医师的关注：子宫内膜异
位症可能不仅是一种良性疾病，还可能与恶性肿瘤的发生密切相关。当前的研究表明子宫内膜异位症的病理机制涉及炎症
反应、激素失调以及基因变异等因素，这些机制共同促进了肿瘤的发生 [2]。尽管已有一些相关研究成果，但该领域仍然存
在诸多争议和未解之谜，包括具体的生物标志物及其临床应用潜力的探讨。因此，本文旨在系统回顾子宫内膜异位症与妇
科肿瘤之间的关联，分析其病理机制，评估现有研究的局限性，并提出未来研究的方向，以期能为临床诊断和治疗提供参考。
关键词
全文:
PDF参考
[1] Bahall V, De Barry L, Jaggernauth C. Clear cell carcinoma
palisading in a focus of endometriosis on the uterine serosa - A
case report and review of the literature. Case Rep Womens Health.
2022 Jul 2;35:e00428.
[2].Kajiyama H, Suzuki S, Yoshihara M, Tamauchi S,
Yoshikawa N, Niimi K, Shibata K, Kikkawa F. Endometriosis and
cancer. Free Radic Biol Med. 2019 Mar;133:186-192.
[3]Bogani G, Chiappa V, Raspagliesi F, Corso G.
Endometriosis and cancer risk. Eur J Cancer Prev. . Published
online Mar 12,2025.
[4]. Brubel R, Polgar B, Szereday L, et al. Alteration of Serum
Gal-3 Levels in Endometrium-Related Reproductive Disorders.
Int J Mol Sci. 2025;26(4). Published 2025 Feb 14.
[5].Lenz J. Atypical Endometriosis - An Overview of the
Issue and Personal Experiences. Cesk Patol. 2025;60(4):185-192.
[6].Soroczynska K, Zareba L, Dlugolecka M, Czystowska-
Kuzmicz M. Immunosuppressive Extracellular Vesicles as a
Linking Factor in the Development of Tumor and Endometriotic
Lesions in the Gynecologic Tract. Cells. 2022;11(9). Published
2022 Apr 28.
[7] 刘炼娥 , 吴红霞 , 张素仙 . 半乳糖凝集素在子宫内膜
异位症中的研究进展 [J]. 昆明医科大学学报 ,2025,46(03):159-
163.
[8]. Jamani NA, Nusee Z, Hamizah I. The bleeding umbilicus:
An uncommon presentation of endometriosis. Med J Malaysia.
2022;77(1):132-134.
[9].Mezzapesa F, Dondi G, Coada CA, et al. Two possible
entities of endometriosis-associated ovarian cancer: correlated or
incidental? Int J Gynecol Cancer. :101634. Published online Jan
10,2025.
[10].Centini G, Ginetti A, Colombi I, et al. Endometriosis
of the appendix: prevalence, associated lesions, and proposal
of pathogenetic hypotheses. A retrospective cohort study
with prospectively collected data. Arch Gynecol Obstet.
2024;310(3):1669-1675.
[11].Hong J, Yi KW. What is the link between endometriosis
and adiposity? Obstet Gynecol Sci. 2022;65(3):227-233.
[12].Rowlands IJ, Hockey R, Abbott JA, Montgomery GW,
Mishra GD. Body mass index and the diagnosis of endometriosis:
Findings from a national data linkage cohort study. Obes Res Clin
Pract. 2022 May-Jun;16(3):235-241.
[13].Bouchacourt L, Smith S, Mackert M, et al. Strategies to
Implement a Community-Based, Longitudinal Cohort Study: The
Whole Communities-Whole Health Case Study. JMIR Form Res.
8:e60368. Published 2024 Dec 5.
[14] 钟 美 . 系 统 免 疫 炎 症 指 数 及 其 联 合 CA125 在 卵
巢 型 子 宫 内 膜 异 位 症 中 的 临 床 应 用 [D]. 南 昌 大 学 ,2024.
DOI:10.27232/d.cnki.gnchu.2024.004153.
[15] 王阳阳 .ARID1A 与 PIK3CA 在卵巢子宫内膜异位症
恶变中的作用及意义 [D]. 郑州大学 ,2022.DOI:10.27466/d.cnki.
gzzdu.2022.001191.
[16].4Brubel R, Polgar B, Szereday L, et al. Alteration of
Serum Gal-3 Levels in Endometrium-Related Reproductive
Disorders. Int J Mol Sci. 2025;26(4). Published 2025 Feb 14.
Sorbi F, Capezzuoli T, Saso S, et al. The relation between
endometrioma and ovarian cancer. Minerva Obstet Gynecol.
2021;73(3):347-353.
Payton JI, Chiodo MV, Webster N. Incidental Abdominal
Wall Endometriosis in Plastic Surgery: Two Cases and Review of
the Literature. Plast Reconstr Surg Glob Open. 2024;12(6):e5871.
Published 2024 Jun.
Mortlock S, Corona RI, Kho PF, et al. A multi-level
investigation of the genetic relationship between endometriosis
and ovarian cancer histotypes. Cell Rep Med. 2022;3(3):100542.
Published 2022 Mar 15.
[20].Huang JY, Ma KS, Wang LT, et al. The Risk of
Endometrial Cancer and Uterine Sarcoma Following Endometriosis
or Pelvic Inflammatory Disease. Cancers (Basel). 2023;15(3).
Published 2023 Jan 29.
[21].Kim J, Bang H, Seong C, Kim ES, Kim SY. Transcription
factors and hormone receptors: Sex‑specific targets for cancer
therapy (Review). Oncol Lett. 2025;29(2):93. Published 2025 Feb.
[22].Zhang T, He Y, Man GCW, Ding Y, Wang CC, Chung
JPW. Myeloid-derived suppressor cells: A new emerging player in
endometriosis. Int Rev Cell Mol Biol. 375:191-220.
[23].Zhang XY, Zheng LW, Li CJ, et al. Dysregulated
Expression of Long Noncoding RNAs in Endometriosis. Crit Rev
Eukaryot Gene Expr. 2019;29(2):113-121.
[24]Kalaitzopoulos DR, Mitsopoulou A, Iliopoulou SM,
Daniilidis A, Samartzis EP, Economopoulos KP. Association
between endometriosis and gynecological cancers: a critical review
of the literature. Arch Gynecol Obstet. 2020;301(2):355-367.
[25]Wang M, Fan R, Jiang J, et al. PIM2 Promotes the
Development of Ovarian Endometriosis by Enhancing Glycolysis
and Fibrosis. Reprod Sci. 2023;30(9):2692-2702.
(3 摘要 Views, 9 PDF Downloads)
Refbacks
- 当前没有refback。