利用无创肝脏瞬时弹性成像评估 HP 感染与 NAFLD 的关系
摘要
发生脂肪变性严重程度的关系。方法:本研究纳入 2023-03-01 至 2024-12-31 日我院行无创肝脏瞬时弹性成像(TE)的
NAFLD 患者 124 例,收集碳 13 呼气试验结果及临床和生化资料,将 NAFLD 患者按脂肪衰减程度(CAP)值分为轻度脂
肪变性组和中重度脂肪变性组,分析 HP 感染与患者 CAP 的关系。结果:中重度组 HP 阳性率更高,差异具有统计学意义(P
< 0.05),中重度组空腹血糖、尿酸、HGB、GGT 和 WBC 水平较高,轻度组 PGII 较高,差异有统计学意义(P < 0.05),
使用 Logistic 回归分析进行单因素分析 HP 阳性是中重度脂肪肝的危险因素(P < 0.05),调整年龄、空腹血糖、尿酸、
GGT、WBC、HGB 和 PGII 后 HP 阳性仍然是中重度脂肪肝的危险因素(P < 0.05),且 OR 值较单因素分析上升。结论:
利用无创肝脏瞬时弹性成像分析,中重度肝脂肪变性组患者 HP 阳性率较高,且 HP 感染是中重度脂肪变性的独立危险因素。
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[1]Younossi, ZM, Koenig, AB, Abdelatif, D, et al. Global
epidemiology of nonalcoholic fatty liver disease-Meta-
analytic assessment of prevalence, incidence, and outcomes.
HEPATOLOGY. 2016; 64 (1): 73-84.
[2]Sun, YD, Zhang, H, Han, JJ. [Non-alcoholic fatty liver
disease: a new challenge for prevention and treatment of hepatic
malignancies]. Zhonghua Nei Ke Za Zhi. 2022; 61 (9): 1074-1079.
[3]Wong, VW, Chu, WC, Wong, GL, et al. Prevalence of non-
alcoholic fatty liver disease and advanced fibrosis in Hong Kong
Chinese: a population study using proton-magnetic resonance
spectroscopy and transient elastography. GUT. 2011; 61 (3): 409-15.
[4]McColl KE. Clinical practice. Helicobacter pylori
infection. N Engl J Med. 2010 Apr 29;362(17):1597-604.
[5]Wei L, Ding HG. Relationship between Helicobacter
pylori infection and nonalcoholic fatty liver disease: What should
we expect from a meta-analysis? Medicine (Baltimore). 2021 Aug
6;100(31):e26706.
[6]Polyzos SA, Kountouras J. Helicobacter pylori infection
and nonalcoholic fatty liver disease: Time for large clinical
trials evaluating eradication therapy. Helicobacter. 2019
Jun;24(3):e12588.
[7]Polyzos SA, Kountouras J. Nonalcoholic Fatty Liver
Disease andHelicobacter pyloriInfection: Is it Time to Address this
Potential Relationship? Curr Vasc Pharmacol. 2023;21(2):78-80.
[8]Mavilia-Scranton MG, Wu GY, Dharan M. Impact
ofHelicobacter pyloriInfection on the Pathogenesis and
Management of Nonalcoholic Fatty Liver Disease. J Clin Transl
Hepatol. 2023 Jun 28;11(3):670-674.
[9]Heydari K, Yousefi M, Alizadeh-Navaei R. Helicobacter
pylori Infection and Non-alcoholic Fatty Liver Disease: A
Systematic Review and Meta-Analysis. Turk J Gastroenterol. 2022
Mar;33(3):171-181.
[10]Sumida Y, Kanemasa K, Imai S. Helicobacter pylori
infection might have a potential role in hepatocyte ballooning
in nonalcoholic fatty liver disease. J Gastroenterol. 2015
Sep;50(9):996-1004.
[11]Doulberis M, Srivastava S, Polyzos SA,.
Active Helicobacter pyloriInfection is Independently Associated
with Nonalcoholic Steatohepatitis in Morbidly Obese Patients. J
Clin Med. 2020 Mar 30;9(4):933.
[12] 孔嘉宁 , 张彬彬 , 施军平 .《代谢相关(非酒精性)
脂肪性肝病防治指南(2024 年版)》解读 [J]. 临床肝胆病杂
志 ,2024,40(09):1767-1770.
[13]Vernon, G, Baranova, A, Younossi, ZM. Systematic
review: the epidemiology and natural history of non-alcoholic fatty
liver disease and non-alcoholic steatohepatitis in adults. Aliment
Pharmacol Ther. 2011; 34 (3): 274-85.
[14]Wang, J, Dong, F, Su, H, et al. H. pylori is related to
NAFLD but only in female: A Cross-sectional Study. Int J Med
Sci. 2021; 18 (11): 2303-2311.
[15]Parnell, JA, Raman, M, Rioux, KP, et al. The potential
role of prebiotic fibre for treatment and management of non-
alcoholic fatty liver disease and associated obesity and insulin
resistance. LIVER INT. 2011; 32 (5): 701-11.
[16] Kim, TJ, Sinn, DH, Min, YW, et al. A cohort study on
Helicobacter pylori infection associated with nonalcoholic fatty
liver disease. J GASTROENTEROL. 2017; 52 (11): 1201-1210.
[17] 卢丽莎 .HP 感染和非酒精性脂肪肝的相关性及其可
能作用的分子机制研究 [D]. 甘肃中医药大学 ,2023.
[18]Li M, Shen Z, Li YM. Potential role of Helicobacter pylori
infection in nonalcoholic fatty liver disease. World J Gastroenterol.
2013;19(41):7024-31.
[19] 赵 光 耀 , 吴 龙 云 , 夏 巧 云 , 等 .HP 感 染 与 非 酒 精
性脂肪肝的联系及其机制的研究进展 [J]. 复旦学报 ( 医学
版 ),2024,51(06):1002-1008.
[20]Yan, P, Yu, B, Li, M, et al. Association between
nonalcoholic fatty liver disease and Helicobacter pylori infection
in Dali City, China. SAUDI MED J. 2021; 42 (7): 735-741.
[21]Yan, P, Yu, B, Li, M, et al. Association between
nonalcoholic fatty liver disease and Helicobacter pylori infection
in Dali City, China. SAUDI MED J. 2021; 42 (7): 735-741.
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