HIV-1 感染者中携带人白细胞抗原 B*57:01 阳性率的研究
摘要
原位杂交技术（FISH），即根据碱基互补配对原则，通过带有荧光物质的探针与目标 DNA 结合，最后通过观察荧光信号
确定基因型，对 HLA-B*57:01 阳性率数据进行比较，设检验水准 α=0.05，用 SPASS26.0 软件做卡方检验。结果：353 名
HIV-1 阳性感染者中，13 人携带 HLA-B*57:01 等位基因，阳性率为 3.68%；其中汉族人 150 人，5 人携带 HLA-B*57:01
等位基因，阳性率为 3.33%；其他民族 203 人，8 人携带 HLA-B*57:01 等位基因，阳性率为 3.94%。结论：人群感染
HIV-1 的感染者中 HLA-B*57:01 阳性率低于国外黑种人和白种人的研究数据，但和我国其他省份地区的数据相比较较高。
关键词
全文:
PDF参考
[1]Alsaeed A, Alkhadrawi Z, Alsadah B, et al.Prevalence of the
HLA-B*5701 Allele and Abacavir Hypersensitivity in Saudi HIV
Patients: A Multicenter Study[J].Cureus,2023, 15(11): e48229.
[2]Fan,W L,Shiao,M S,Hui,R C,Su,S C,Wang,C W,Chang,Y
C,Chung,W H.HLA associationwith drug-induced adverse
reactions[J].Immunol Res,2017,3186328.
[3]Jesson J,Dahourou DL,Renaud F,Penazzato M,Leroy
V.Adverse events associated with abacavir use in HIV-infected
children and adolescents:a systematic review and meta-analysis[J].
Lancet HIV,2016,3:e64-e75.
[4]Eugenia Quiros-Roldana,Giulia Gardinia,etal.Abacavir
adverse reactions related with HLA-B*57:01 haplotype in a large
cohort of patients infected with HIV[J].Pharmacogenetics and
Genomics,2020,30(8):167-174D
[5]Mallal S,Phillips E,Carosi G,Molina,J M,Workman
C,Tomazic J,Jagel,Guedes E, Rugina S,Kozyrev O,Cid J F,Hay
P,Nolan D,Hughes S,Hughes A,Ryan S,Fitch N,Thorborn,Benbow
A Study Team.HLAB*57:01 screening for hypersensitivity to
abacavir [J].N.Engl,2008,358 (6):568-579.
[6]Kolou M,Poda A,Diallo Z,Konou E,Dokpomiwa
T,Zoungrana J,Salou M,MbaTchounga L, Bigot A,Ouedraogo A
S,Bouyout-Akoutet M,Ekouevi D K,Eholie S P.Prevalence of
human leukocyte antigen HLA-B*57:01 in individuals with HIV
in West and Central Africa[J].BMC Immunol,2021,22 (1):48.
[7] 李星美 , 姚均 , 马名驹 , 等 . 四川凉山静脉吸毒人群
HIV 感染者中 HLA-B*57:01 阳性率的研究 [J]. 中国艾滋病性
病 ,2011(4):404-406,438.
[8] 靳廷丽 , 刘丽萍 , 易志强 , 唐翼龙 , 张娜 , 廖清华 . 江
西省艾滋病病毒感染者 HLA-B*57:01 阳性率的研究 [J]. 现代
预防医学 ,2014,41(21):3987-3989
[9]S W C To MBioChem, J H K Chen PhD, K H Wong MD,
K C W Chan MD, O T Y Tsang MD, W C Yam PhD.HLA-B*5701
genetic screening among HIV-1 infected patients in Hong Kong:
is this a practical approach in Han-Chinese?[J].International
Journal of STD & AIDS, 2013,24: 50-52.
[10] 中国艾滋病诊疗指南（2024 版）
[11]《国家免费艾滋病抗病毒药物治疗手册（2023 年版）》
[12]Imane Belbacha a,b, Soumia Benchekroun c, Rajae
Bensghir d, Kamal Filali Marhoum d,Elharti Elmir a, Khalid Sadki
b, Hicham Oumzil a.A prospective epidemiological investigation of
human leukocyte antigen-B*57:01 in HIV-1-infected Moroccan
subjects[J].Human Gene,2024, 42:201324
[13]Rauch A, Nolan D, Martin A, McKinnon E, Almeida C,
Mallal S. Prospective genetic screening decreases the incidence of
abacavir hypersensitivity reactions in the Western Australian HIV
cohort study[J]. Clin. Infect. Dis,2006, 43 (1):99-102.
[14]Zucman D,Truchis P D,Majerholc C,Stegman
S,Caillat-Zucman S.Prospective screening for human leukocyte
antigen-B*5701 avoids abacavir hypersensitivity reaction in the
ethnically mixed French HIV population[ J]. Acquir.Immune
Defic. Syndr,2007,45(1):1-3.
[15]Hewitt RG. Abacavir hypersensitivity reaction[J]. Clin
Infect Dis, 2002, 34:1137-1142.
[16]Eugenia Quiros-Roldana,Giulia Gardinia,Martina
Properzia,Alice Ferraresia,Graziella Carellab,Alessandro
Marchia,Alberto Malagolib,Emanuele Focàaand Francesco
Castellia.Abacavir adverse reactions related with HLA-B*57:01
haplotype in a large cohort of patients infected with HIV[J].
Pharmacogenetics and Genomics,2020,30(8):167-174
[17]Illing PT,Vivian JP,Dudek NL,Kostenko L,Chen
Z,Bharadwaj M, etal. Immune self-reactivity triggered by drug-
modified HLA-peptide repertoire[J].Nature 2012,486:554-558
[18]Ostrov DA,Grant BJ,Pompeu YA,Sidney J,Harndahl
M,Southwood S,etal.Drug hypersensitivity caused by alteration of
the MHC-presented selfpeptide repertoire[J]. Proc Natl AcadSci
USA,2012,109:9959-9964.
(4 摘要 Views, 10 PDF Downloads)
Refbacks
- 当前没有refback。