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三阴性转移性乳腺癌免疫治疗的研究进展

牛 朝洋, 汝 蕊, 赵 野, 宗 禹萱, 尹 佳新, 周 飞*

摘要

在女性人群中,乳腺癌发病率特别高,是癌症致死的主要原因之一。乳腺癌的免疫治疗通过调节人体的免疫系统来降低肿瘤的致死率,是目前兴起的治疗方法。现阶段有大量的临床实验正在进行中,尚未应用于临床,但对乳腺癌的治疗有导向作用。本文通过介绍肿瘤微环境和免疫逃逸去说明免疫治疗所面临的问题及针对程序性死亡受体1(PD-1)/程序性死亡受体配体1(PD-L1)抑制剂和ALDH1A1重塑免疫/微环境促进肿瘤生长两个方面去介绍乳腺癌免疫治疗的最新进展。尽管免疫治疗面临诸多问题,但在三阴性转移性乳腺癌中效果显著。本文旨在总结免疫治疗的方法和问题,为临床工作提供指导及方向。

关键词

肿瘤微环境;免疫逃逸;ALDH1A1;免疫检查点抑制剂;三阴性转移性乳腺癌

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参考

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