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球内注射雷珠单抗联合全视网膜光凝治疗新生血管青光眼

刘 新颜, 陈 晓亚, 刘 光艳, 孙 燚, 王 芳, 杨 均伟

摘要

目的 探讨球内注射雷珠单抗联合全视网膜光凝治疗新生血管青光眼(NVG)的安全性和效果。方法 选择泰安八十八医院眼科 2022年11月-2024年11月收治的 59例 NVG 患者,分为两组,观察组33 眼为球内注射雷珠单抗联合全视网膜光凝治疗, 对照组26 眼为单纯全视网膜光凝治疗。观察随访至少 3 个月,比较各组视力、裂隙灯显微镜下角膜透明情况、虹膜新生血管消退情况、非接触眼压计测量眼压、视野、光学相干断层扫描测量视神经中心3.45mm直径范围内的视网膜神经纤维层厚度等。结果 观察至术后 3个月时,两组患者的视力、眼压、虹膜新生血管消退情况、视神经纤维层(RNFL)厚度、视野缺损程度等病情指标,发现视力、眼压、虹膜新生血管消退情况均较术前明显改善,且观察组优于对照组,差异有统计学意义(P<0.05),RNFL厚度、视野缺损程度治疗前后及两组间比较无统计学差异。结论 球内注射雷珠单抗联合全视网膜光凝治疗NVG患者,疗效显著,可促进新生血管消退,有助改善患者的眼部生理结构,促进视力水平恢复,提高患者生存质量。

关键词

新生血管性青光眼;全视网膜激光光凝术;雷珠单抗

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参考

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