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三细胞连接与流体剪切应力串联在动脉粥样硬化中的作用

高红果, 顾耘

摘要

动脉粥样硬化（atherosclerosis，AS）是一种多发于中大动脉血管壁的慢性炎症性疾病，涉及不同来源的多种细胞类型，以及它们之间复杂的交互作用[1]，其特征是修饰脂蛋白的积累和血管壁内纤维组织的发育[2]。细胞间连接与细胞通讯在AS的发生与治疗中展现出广泛的生物学功能[3]。先天免疫和适应性免疫在AS的动态消长中发挥了重要作用[4]。流体剪切应力（Fluid shear stress，FSS）是由液体（如血液或间质液）流动产生的摩擦阻力，在调节细胞基因表达和功能表型中起着关键作用[5]。FSS介导的内皮细胞（endothelialcell，EC）损伤与炎症反应会触发AS生成。三细胞连接（Three cell junction，TCJ）是指三个上皮细胞或EC在其顶端接触的部位形成的特殊细胞间连接，是调节水、离子和大分子穿过内皮的细胞旁通道[6]，在组织稳态、病原体防御以及感知张力和细胞形状方面起着重要作用[7]，作为FSS的敏感热点，在血流动力及牵张机械力的影响下，其拓扑结构及渗透率会发生相应改变[8]。该文章拟在阐述TCJ与FSS串联在AS中的作用。

关键词

动脉粥样硬化；三细胞连接；流体剪切应力；串联

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参考

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