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LncRNA在食管癌诊疗中的研究进展

赵长昆, 吴若男, 陈玲, 刀金华, 张新鹏*

摘要

食管癌（esophageal cancer，ESCA）是一种在消化系统中常见的恶性肿瘤，而食管鳞状细胞癌（esophageal squamous cell carcinoma，ESCC）是其一种亚型。近期的研究揭示了长链非编码RNA（longnon-coding RNA，lncRNA）在ESCC的发病机制中扮演着关键角色。作为一类长度超过200个核苷酸的复杂RNA分子，lncRNA通过多种机制如竞争性内源性通路、与其他RNA和蛋白质的相互作用来调节基因表达。它们在ESCC的细胞增殖、迁移、侵袭、对治疗的耐受性、细胞凋亡、血管生成、自噬以及肿瘤生长等多个方面发挥着核心作用。因此，lncRNA在食管癌的诊断、治疗及预后评估中具有潜在的重要价值，并且正在成为癌症研究的热点。

关键词

食管癌鳞状细胞癌；长链非编码RNA；诊断；治疗

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参考

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