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细胞衰老在血脑屏障的研究进展

刘 倩男, 程 思宇, 蒋 心亮, 王 奕, 谢合 代·, 来孜 娜·

摘要

血脑屏障是调节大脑和血液之间沟通的重要界面,是维护大脑微环境稳态的重要结构,其主要功能是阻止有害物质进入脑组织,同时维持脑组织内环境的相对稳定,对维持中枢神经系统正常生理状态具有重要意义。细胞衰老是细胞处于一种永久性增殖停滞状态。当血脑屏障发生细胞衰老时,血脑屏障的结构和功能则会被破坏而导致血脑屏障渗透率增高,最终会引起神经系统退行性疾病的发生。此文将围绕血脑屏障与细胞衰老的关系进行综述,旨在更好理解细胞衰老过程中血脑屏障的变化,为后续预防和治疗相关疾病提供新的思路和方法。

关键词

细胞衰老;血脑屏障;神经退行性疾病

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参考

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