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Wnt/β-catenin信号通路在中药治疗结肠息肉中作用的研究进展

张 艳丽, 周 缰鹏, 郑 淑琼, 李 玲洁, 张继 红*

摘要

结肠息肉在消化道疾病中的发病率越来越高,当然,这和内镜技术的快速发展密不可分,人们对结肠息肉的认识越来越深刻。现代医学研究发现,息肉的发生与Wnt/β-catenin信号通路的活化紧密相关。中医药在结肠息肉的治疗中具有独到优势,多种单味药如半枝莲、白花蛇舌草、姜黄素、毛兰素、雷公藤红素等,中药复方如半夏泻心汤、黄芩汤、乌梅丸等都可以通过Wnt/β-catenin信号通路治疗结肠息肉及防止息肉的发生,其机制主要是通过抑制β-catenin蛋白在细胞核内的异常聚集,从而阻止Wnt/β-catenin信号通路的活化。

关键词

Wnt/β-catenin信号通路;结肠息肉;中药

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参考

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