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HIV-1感染者中携带人白细胞抗原B*57:01阳性率的研究

宋 玉霞, 周 卫刚, 童 茜, 闫 雪梅, 魏 叶叶, 王 菁*

摘要

目的:探讨新疆地区人类免疫缺陷病毒 (HIV) 感染者中的人白细胞抗原 HLA-B*5701阳性率。方法:采用荧光原位杂交技术(FISH),即根据碱基互补配对原则,通过带有荧光物质的探针与目标DNA结合,最后通过观察荧光信号确定基因型,对HLA-B*57:01阳性率数据进行比较,设检验水准α=0.05,用SPASS26.0软件做卡方检验。结果:353名HIV-1阳性感染者中,13人携带HLA-B*57:01等位基因,阳性率为3.68%;其中汉族人150人,5人携带HLA-B*57:01等位基因,阳性率为3.33%;其他民族203人,8人携带HLA-B*57:01等位基因,阳性率为3.94%。结论:新疆人群感染HIV-1的感染者中HLA-B*57:01阳性率低于国外黑种人和白种人的研究数据,但和我国其他省份地区的数据相比较较高。

关键词

新疆;HIV;HLA-B*57:01

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参考

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