开放期刊系统

阻塞性睡眠呼吸暂停与呼吸系统疾病相关性的研究进展

张 柔, 艾 丽, 李永 霞*

摘要

阻塞性睡眠呼吸暂停 (OSA) 是常见的睡眠相关障碍,其特征为睡眠期间上气道的周期性塌陷,导致机体间歇性缺
氧,进而影响全身多个系统健康。近年来研究发现,OSA 与慢性阻塞性肺疾病、哮喘、肺动脉高压等多种呼吸系统疾病关
系密切。然而,临床上常不重视 OSA 带来的影响,导致单一治疗策略效果不佳。本综述基于国内外的相关研究,综合分析
了 OSA 相关呼吸系统疾病的临床特征、相互作用机制,旨在加强临床相关疾病的综合认识。

关键词

睡眠呼吸暂停;阻塞性;呼吸系统疾病;研究进展

全文:

PDF

参考

[1]ABBASI A,GUOTA SS,SABHARWAL N, et al.A

comprehensive review of obstructive sleep apnea[J].Sleep

Sci,2021,14(2):142-154.

[2] 王晓娜 , 肖毅 .2019 年阻塞性睡眠呼吸暂停领域年度

进展 [J]. 中华医学信息导报 ,2020,35(5):16.

[3]WANG C,XU J,YANG L, et al.Prevalence and risk factors

of chronic obstructive pulmonary disease in China (the China

Pulmonary Health [CPH] study): a national cross-sectional study

[J]. Lancet, 2018,391(10131):1706-1717.

[4]SHAWON MS,PERRET JL,SENARATNA CV, et

al.Current evidence on prevalence and clinical outcomes of co_xfffe_morbid obstructive sleep apnea and chronic obstructive pulmonary

disease: A systematic review[J].Sleep Med Rev,2017,32:58-68.

[5]VAN ZELLER M,MCNICHOLAS WT.Sleep disordered

breathing: OSA-COPD overlap[J].Expert Rev Respir

Med,2024,18(6):369-379.

[6]MACREA M,OCZKOWSKI S,ROCHWERGE B, et

al.Long-Term Noninvasive Ventilation in Chronic Stable

Hypercapnic Chronic Obstructive Pulmonary Disease. An Official

American Thoracic Society Clinical Practice Guideline[J].Am J

Respir Crit Care Med,2020,202(4):e74-e87.

[7]GBD 2019 Chronic Respiratory Diseases Collaborators,.

Global burden of chronic respiratory diseases and risk factors,

1990-2019: an update from the Global Burden of Disease Study

2019[J]. EClinicalMedicine, 2023,59:101936.

[8]HUANG K,YANG T,XU J, et al.Prevalence, risk factors,

and management of asthma in China: a national cross-sectional

study[J].Lancet,2019,394(10196):407-418.

[9] 中国医药教育协会慢性气道疾病专业委员会 , 中国

哮喘联盟 . 重度哮喘诊断与处理中国专家共识 (2024)[J]. 中华

医学杂志 ,2024,104(20):1759-1789.

[10]WANG R,MIHAICUTA S,TIOTIU A, et al.Asthma and

obstructive sleep apnoea in adults and children - an up-to-date

review[J].Sleep Med Rev,2022,61:101564.

[11]CISNEROS C,ITURRICASTILLO G,MARTÍNEZBESTIERO E, et al.Obstructive sleep apnea: The key for a better

asthma control?[J].Sleep Med,2023,101:135-137.

[12]REINDERS S,DIDDEN EM,ONG R.Survival, morbidity,

and quality of life in pulmonary arterial hypertension patients:

a systematic review of outcomes reported by population-based

observational studies[J].Respir Res,2024,25(1):373.

[13]HOEPER MM,HUBERT M,SOUZA R, et al.A global view

of pulmonary hypertension[J].Lancet Respir Med,2016,4(4):306-

322.

[14]LI YE,Ren J.Association between obstructive sleep

apnea and cardiovascular diseases[J].Acta Biochim Biophys Sin

(Shanghai),2022,54(7):882-892.

[15]BALCAN B,AKDENIZ B,PEKER Y, et al.Obstructive

Sleep Apnea and Pulmonary Hypertension: A Chicken-and-Egg

Relationship[J].J Clin Med,2024,13(10):2961.

[16]SAJKOV D,WANG T,SAUNDERS NA, et al.Continuous

positive airway pressure treatment improves pulmonary

hemodynamics in patients with obstructive sleep apnea[J].Am J

Respir Crit Care Med,2002,165(2):152-158.

[17]BRAY F,LAVERSANNE M,SUNG H, et al.Global

cancer statistics 2022: GLOBOCAN estimates of incidence and

mortality worldwide for 36 cancers in 185 countries[J].CA Cancer

J Clin,2024,74(3):229-263.

[18]NIETO FJ,PEPPARD PE,YOUNG T, et al.Sleepdisordered breathing and cancer mortality: results from the

Wisconsin Sleep Cohort Study[J].Am J Respir Crit Care

Med,2012,186(2):190-194.

[19]MARSHALL NS,WONG KK,CULLEN SR, et al.Sleep

apnea and 20-year follow-up for all-cause mortality, stroke, and

cancer incidence and mortality in the Busselton Health Study

cohort[J].J Clin Sleep Med,2014,10(4):355-362.

[20]YUAN F,HU Y,XU F, et al.A review of obstructive

sleep apnea and lung cancer: epidemiology, pathogenesis, and

therapeutic options[J].Front Immunol,2024,15:1374236.

[21]GHARIB SA,SEIGER AN,HAYES AL, et al.Treatment

of obstructive sleep apnea alters cancer-associated transcriptional

signatures in circulating leukocytes[J].Sleep,2014,37(4):709-714,

714A-714T.

[22] 陈 相 , 李 耀 浙 , 傅 扬 扬 , 等 .1990-2019 年 中 国

间 质 性 肺 疾 病 和 肺 结 节 病 的 疾 病 负 担 分 析 [J]. 疾 病 监

测 ,2023,38(04):473-480.

[23] 张晓雷 , 张慧 , 高博 , 等 . 慢性阻塞性肺疾病与致纤

维化型间质性肺疾病患者阻塞性睡眠呼吸暂停对比研究 [J].

中国实用内科杂志 ,2020,40(4):300-305.

[24]PAPADOGIANNIS G,BOULOUKAKI I,MERMIGKIS C,

et al.Patients with idiopathic pulmonary fibrosis with and without

obstructive sleep apnea: differences in clinical characteristics,

clinical outcomes, and the effect of PAP treatment[J].J Clin Sleep

Med,2021,17(3):533-544.


(4 摘要 Views, 6 PDF Downloads)

Refbacks

  • 当前没有refback。