肺损伤诱导的细胞动态与修复再生研究进展
摘要
性低氧性呼吸衰竭。因此，ALI 往往会伴随急性呼吸窘迫综合征（acute respiratory distress syndrome，ARDS），主要病理
特征包括肺泡间隙积聚富含蛋白质的炎性积液、肺泡出血、纤维蛋白沉积、部分肺泡组织塌陷以及间质纤维化。近年来，
不同细胞种类在肺损伤中的病理作用引起了全世界的广泛关注，但是肺损伤时肺部微环境中细胞层次结构和细胞活跃轨迹
的变化仍有待深入探讨。因此，本文综述了 ALI/ARDS 中肺部微环境从上皮开始深入至内皮进而引起的细胞作用机制，旨
在阐述肺泡上皮细胞、肺内皮细胞、巨噬细胞以及招募而来的中性粒细胞介导的肺损伤与修复再生研究进展。
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