辐射诱发白内障的生物学机制新进展
摘要
体上皮细胞的氧化损伤，导致细胞凋亡从而引起白内障。近年来，许多新的生物学机制报道参与晶状体上皮细胞的氧化应激，
如铁死亡等，最终引发白内障。本文依次从基因水平、转录水平和蛋白翻译后修饰水平系统阐述辐射诱发白内障的生物学
机制及新进展，并为后续的研究提供学术参考。
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[1] 李德馨 , 王思玲 , 苏德森 . 白内障的发病机制与药物
治疗 [J]. 沈阳药科大学学报 ,2002,19(4):300-307.
[2] 陈莺 , 陈大本 . 白内障发病机制及预防治疗的研究进
展 [J]. 眼科新进展 ,2005,25(2):190-193.
[3] Ø ster å s B H , J e n s e n K , A n d e r s e n H K , e t
al.Strålingsindusert katarakt [Radiation-induced cataracts][J].
Tidsskr Nor Laegeforen. 2016 136(21):1809-1812.
[4] 陈文婷 , 张劲松 . 年龄相关性白内障分子生物学机制
的研究进展 [J]. 国际眼科杂志 ,2008,8(5):982-984.
[5]Wang Y, Zhang J, Wu J,et al. Expression of DNA repair
genes in lens cortex of age-related cortical cataract[J]. Exp Mol
Pathol. 2017 102(2):219-223.
[6]Wang Y, Li P, Wang C, et al. Lens epithelium cell
ferroptosis mediated by m6A-lncRNA and GPX4 expression in
lens tissue of age-related cataract[J]. BMC Ophthalmol. 2023
23(1):514.
[7] Tang Y, Liang H, Su L, et al.Ferroptosis: a new
perspective on the pathogenesis of radiation-induced cataracts[J].
Front Public Health. 2024 12:1449216.
[8]Li P, Zhong R, Yu J, et al. DCLRE1A Contributes to
DNA Damage Repair and Apoptosis in Age-Related Cataracts
by Regulating the lncRNA/miRNA/mRNA Axis[J]. Curr Eye Res.
2023 48(11):992-1005.
[9]Kafeel S, Bizenjo N, Shivji SS, et al.DNA Repair Enzyme
XRCC4 30 bp Indel Intron 3 Locus Significant Association with
Predisposition of Cataract in Senility[J]. Appl Biochem Biotechnol.
2024 196(1):99-112.
[10]Wei Z, Hao C, Huangfu J,et al. Aging lens epithelium is
susceptible to ferroptosis[J]. Free Radic Biol Med. 2021 167:94-
108.
[11]Chen Y, Fan H, Wang S, et al. Ferroptosis: a novel
therapeutic target for ischemia-reperfusion injury[J]. Front Cell
Dev Biol. 2021 9:688605.
[12]Chen X, Kang R, Kroemer G,et al. Broadening horizons:
the role of ferroptosis in cancer[J]. Nat Rev Clin Oncol. 2021
18:280–296.
[13]Liao S, Huang M, Liao Y, et al.HMOX1 Promotes
Ferroptosis Induced by Erastin in Lens Epithelial Cell through
Modulates Fe Production[J]. Curr Eye Res. 2023 48(1):25-33.
[14]Ma DY, Liu JX, Wang LD, et al.GSK-3β-dependent
Nrf2 antioxidant response modulates ferroptosis of lens epithelial
cells in age-related cataract[J]. Free Radic Biol Med. 2023
204:161-176.
[15]Kong D, Liu Y, Li L, et al.Astaxanthin ameliorates
oxidative stress in lens epithelial cells by regulating GPX4 and
ferroptosis[J]. Chem Biol Interact. 2023 S383:110684.
[16]Azizova TV, Hamada N, Grigoryeva ES, et al. Risk of
various types of cataracts in a cohort of Mayak workers following
chronic occupational exposure to ionizing radiation[J]. Eur J
Epidemiol. 2018 33:1193–1204.
[17]Mi Y, Wei C, Sun L,et al.Melatonin inhibits ferroptosis
and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4
and SIRT6/NCOA4/FTH1 pathways[J]. Biomed Pharmacother.
2023 157:114048.
[18]Wang L, Liu J, Ma D, et al. Glycine recalibrates iron
homeostasis of lens epithelial cells by blocking lysosome-
dependent ferritin degradation[J]. Free Radic Biol Med. 2024
210:258-270.
[19]Zhao Z, Chen J, Yuan W, et al.Association between
single nucleotide polymorphisms in exon 3 of the alpha-A-
crystallin gene and susceptibility to age-related cataract[J].
Ophthalmic Genet. 2023 44(2):127-132.
[20]Zou X, Zhang J, Wang Y, et al.IGF-1 rs6218
polymorphisms modulate the susceptibility to age-related
cataract[J]. PeerJ. 2024 12:e17220.
[21]Cui YL, Yu XN, Zhang X, et al. Association of IGF1R
polymorphisms (rs1546713) with susceptibility to age-related
cataract in a Han Chinese population[J]. Int J Ophthalmol. 2020
13(3):374-381.
[22]Zou X, Wang H, Zhou D, et al. The Polymorphism rs2968
of LSS Gene Confers Susceptibility to Age-Related Cataract[J].
DNA Cell Biol. 2020 39(11):1970-1975.
[23]Delas F, Koller S, Feil S, et al. Novel CRYGC Mutation
in Conserved Ultraviolet-Protective Tryptophan (p.Trp131Arg) Is
Linked to Autosomal Dominant Congenital Cataract[J]. Int J Mol
Sci. 2023 24(23):16594.
[24]Fox JC, Dutta R, Nihalani BR, et al.Identification of
pathogenic genetic variants in patients with acquired early-onset
bilateral cataracts using next-generation sequencing[J]. J AAPOS.
2024 28(1):103808. .
[25]Shi X, Xue Z, Ye K, et al. Roles of non-coding RNAs
in eye development and diseases[J]. Wiley Interdiscip Rev RNA.
2023 14(5):e1785.
[26]Chen S, Zhang C, Shen L, et al. Noncoding RNAs in
cataract formation: Star molecules emerge in an endless stream[J].
Pharmacol Res. 2022 184:106417.
[27]Dong Y, Zheng Y, Xiao J,et al.MicroRNA let-7b induces
lens epithelial cell apoptosis by targeting leucine-rich repeat
containing G protein-coupled receptor 4 (Lgr4) in age-related
cataract[J]. Exp Eye Res. 2016 147:98-104.
[28]Wu Q, Liu H, Ma B, et al. Circular RNA Circ_0122396
Regulates Human Lens Epithelial Cell Progression by Regulating
miR-23a-3p and MMP16 in Age-Related Cataract[J]. Curr Eye
Res. 2024 49(11):1161-1170.
[29]Luo J, Li P, Kang L,et al. Exosomal microRNA-222-3p
increases UVB sensitivity of lens epithelium cells by suppressing
MGMT[J]. Int Ophthalmol. 2023 43(5):1611-1628.
[30]Li H, Ji L, Shen H, et al.The Long Noncoding RNA H19
Promotes Fibrotic Processes in Lens Epithelial Cells[J]. Invest
Ophthalmol Vis Sci. 2023 64(7):21.
[31]Zhou T, Zhang J, Qin B,et al. Long noncoding RNA
NONHSAT143692.2 is involved in oxidative DNA damage repair
in the lens by regulating the miR47285p/OGG1 axis[J]. Int J Mol
Med. 2020 46(5):1838-1848.
[32]Zhou C, Huang X, Li X, et al.Circular RNA erythrocyte
membrane protein band 4.1 assuages ultraviolet irradiation-
induced apoptosis of lens epithelial cells by stimulating
5’-bisphosphate nucleotidase 1 in a miR-24-3p-dependent
manner[J]. Bioengineered. 2021 12(1):8953-8964.
[33]Sun L, Li F, Bai S, et al.CircRNA HLCS regulates lens
epithelial cell apoptosis via miR-338-3p/BPNT1 axis[J]. Int
Ophthalmol. 2024 44(1):142.
[34]Ling X, Zhu L, Yan Y, et al. Ferulic Acid Protects
Human Lens Epithelial Cells Against UVA-Induced Oxidative
Damage by Downregulating the DNA Demethylation of the Keap1
Promoter[J]. J Biochem Mol Toxicol. 2024 38(11):e70031.
[35]Palsamy P, Bidasee KR, Shinohara T. Valproic acid
suppresses Nrf2/Keap1 dependent antioxidant protection through
induction of endoplasmic reticulum stress and Keap1 promoter
DNA demethylation in human lens epithelial cells[J]. Exp Eye
Res. 2014 121:26-34.
[36] Yang SP, Yang XZ, Cao GP. Acetyl-l-carnitine prevents
homocysteine-induced suppression of Nrf2/Keap1 mediated
antioxidation in human lens epithelial cells[J]. Mol Med Rep. 2015
12(1):1145-1150.
[37]Periyasamy P, Shinohara T. Age-related cataracts: Role
of unfolded protein response, Ca2+ mobilization, epigenetic DNA
modifications, and loss of Nrf2/Keap1 dependent cytoprotection[J].
Prog Retin Eye Res. 2017 60:1-19.
[38]Wang L, Zhu D, Yang Y,et al.DNA hypermethylation
of COL4A1 in ultraviolet-B-induced age-related cataract
models in vitro and in vivo[J]. Int J Ophthalmol. 2024
17(10):1791-1799.
[39]Chung KW, Choi YJ, Park MH,et al. Molecular Insights
into SIRT1 Protection Against UVB-Induced Skin Fibroblast
Senescence by Suppression of Oxidative Stress and p53
Acetylation[J]. J Gerontol A Biol Sci Med Sci. 2015 70(8):959-68.
[40]Wu F, Xia X, Lei T, et al.Inhibition of SIRT1 promotes
ultraviolet B induced cataract via downregulation of the KEAP1/
NFE2L2 signaling pathway[J]. J Photochem Photobiol B. 2023
245:112753.
[41]Nandi SK, Nahomi RB, Harris PS, et al.The absence
of SIRT3 and SIRT5 promotes the acetylation of lens proteins
and improves the chaperone activity of α-crystallin in mouse
lenses[J]. Exp Eye Res. 2019 182:1-9.
[42]Rong X, Qiu X, Jiang Y,et al.Effects of histone acetylation
on superoxide dismutase 1 gene expression in the pathogenesis of
senile cataract[J]. Sci Rep. 2016 6:34704.
[43]Wang Y, Li F, Zhang G, et al. Ultraviolet-B induces
ERCC6 repression in lens epithelium cells of age-related nuclear
cataract through coordinated DNA hypermethylation and histone
deacetylation[J]. Clin Epigenetics. 2016 May 26;8:62.
[44]Wu A, Zhang W, Zhang G, et al. Age-related cataract:
GSTP1 ubiquitination and degradation by Parkin inhibits its anti-
apoptosis in lens epithelial cells[J]. Biochim Biophys Acta Mol
Cell Res. 2023 1870(4):119450.
[45]Zhang W, Wu A, Zhang G, et al.Ubiquitination of Ku70
by Parkin promotes apoptosis of lens epithelial cells[J]. FEBS J.
2023 290(15):3828-3842.
[46]Mao X, Ji M, Kang L,et al. XRCC5 downregulated by
TRIM25 is susceptible for lens epithelial cell apoptosis[J]. Cell
Signal. 2022 94:110314.
[47]Deng Y, Shi Y, Wen C. TRIM3 Inhibits H2O2-Induced
Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via
Ubiquitination[J]. Curr Eye Res. 2022 47(5):747-752.
[48]Meng K, Fang C. Knockdown of Tripartite motif-
containing 22 (TRIM22)relieved the apoptosis of lens epithelial
cells by suppressing the expression of TNF receptor-associated
factor 6 (TRAF6)[J]. Bioengineered. 2021 12(1):7213-7222.
[49] Qi T, Jing R, Ma B, et al. The E3 Ligase RNF157
Inhibits Lens Epithelial Cell Apoptosis by Negatively Regulating
p53 in Age-Related Cataracts[J]. Invest Ophthalmol Vis Sci. 2022
63(4):11.
[50] Chen X, Zhang G, Li P,et al. SYVN1-mediated
ubiquitination and degradation of MSH3 promotes the apoptosis of
lens epithelial cells[J]. FEBS J. 2022 289(18):5682-5696.
[51] Wang Y, Wang JM, Xiao Y,et al.SUMO1-regulated
DBC1 promotes p53-dependent stress-induced apoptosis of lens
epithelial cells[J]. Aging (Albany NY). 2023 15(17):8812-8832.
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