2 例儿童重症感染持续输注万古霉素的病例分析及文献复习
摘要
优化万古霉素给药方案，给予持续输注万古霉素的诊疗过程。结果：优化万古霉素给药方案后 ，患儿可快速达到目标浓度，
其中例 2 患儿目标浓度持续平稳，2 例患儿感染均较前明显控制，且未见肾毒性等不良反应，很快转至普通病房继续治疗，
最终顺利出院。 结论：初步观察持续输注万古霉素可以快速达到稳态血药浓度，有助于控制严重感染。
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[1] 汪复 , 张婴元 . 实用抗感染治疗学第２版 [ Ｍ ]. 人民
卫生出版社 .2017.365-368
[2] 范洪伟 , 王焕玲 , 等 . 桑德福抗微生物治疗指南（新
译第 50 版）
[ Ｍ ]. 中国协和医科大学出版社 .2022.75
[3]ZELENITSKY S， RUBINSTEIN E， ARIANOR， et
al. Vancomycin pharmacodynamics and survival in patients with
methicillin-resistant Staphylococcus aureus-associated septic
shock [J]. Int J Antimicrob Agents， 2013， 41（3）：255-
260.
[4]BROWN J， BROWN K， FORREST A. Vancomycin
AUC24/ MIC ratio in patients with complicated bacteremia and
infective endocarditis due to methicillin -resistant Staphylococcus
aureus and its association with attributable mortality during
hospitalization [J]. Antimicrob Agents Chemother， 2012， 56（2）：
634-638.
[5]Bryan D Lizza,Nick Raush,Scott T. Micek. Antibiotic
Optimization in the Intensive Care Unit .Semin Respir Crit Care
Med.2022,43(1):125-130.
[6] 郑小娟，程燕燕，吴梅花，等 . 万古霉素致红人综合
征的文献分析 [J]. 临床合理用药杂志，2019，12（3A):130-131.
[7]NEELY MN，KATO L，YOUN G，et al. Prospective
trial on the use of trough concentration versus area under the curve
to determine therapeutic vancomycin dosing[J]. Antimicrob Agents
Chemother，2017. DOI：10.1128/AAC. 02042-17.
[8] 范亚新，张菁 . 万古霉素药动学 / 药效学及个体化
给药 [J]. 中国感染与化疗杂志，2019，19(3):323-330.
[9]Michael J. Rybak,Jennifer Le.Therapeutic Monitoring
of Vancomycin for Serious MethicillinResistant
Staphylococcus Aureus Infections: A Revised Consensus
Guideline and Review by the American Society of Health-System
Pharmacists, the Infectious Diseases Society of America, the
Pediatric Infectious Diseases Society, and the Society of Infectious
Diseases Pharmacists.Revised Vancomycin Consensus Guideline
·CID,2020,71(15):1361-1364.
[10]Van Maarseveen E.M., Gipmans S.G.H., Van
Zanten A.R.H. Exposure Variability and Target Attainment of
Vancomycin: A Systematic Review Comparing Intermittent and
Continuous Infusion.Ther Drug Monit.2020 ,42(3):381-391.
[11] 刘 露 , 吴 知 桂 , 等 . 万 古 霉 素 持 续 输 注 与 间
歇 输 注 有 效 性 与 安 全 性 比 较 的 Meta 分 析 [J]. 中 国 药
房 ,2020,31(22):2774-2780.
[12]Jing-Jing Hao, Han Chen, Jian-Xin Zhou.Continuous
versus intermittent infusion of vancomycin in adult patients: A
systematic review and meta-analysis.International Journal of
Antimicrobial Agents.2016,47(1):28-35.
[13]Flannery AH, Bissell BD, Bastin MT, et al. Continuous
Versus Intermittent Infusion of Vancomycin and the Risk of Acute
Kidney Injury in Critically III Adults: A Systematic Review and
Meta-Analysis. Crit Care Med. 2020,48(6):912-918.
[ 1 4 ] Y a n g C h u , Y i F a n L u o , e t a l . I n t e r m i t t e n t v s .
continuous vancomycin infusion for gram-positive infections:
A systematic review and meta-analysis.J Infect Public
Health.2020,13(4):591-597.
[15]Amanda Gwee, Noel Cranswick.Continuous Versus
Intermittent Vancomycin Infusions in Infants: A Randomized
Controlled Trial.Pediatrics 2019.143(2)
[16]Louise Whitticase, Gemma Holder, Matt Cawsey,
Alison Bedford-Russell.AN AUDIT OF VANCOMYCIN
PLASMA CONCENTRATIONS WHEN VANCOMYCIN
IS ADMINISTERED BY CONTINUOUS INTRAVENOUS
INFUSION IN NEONATES.Arch Dis Child .2016,101(9):A1–
A37
[17]Marta Alonso-Moreno ,Marta Mejías-Trueba , Laura
Herrera-Hidalgo.Effificacy and Safety of Continuous Infusion of
Vancomycin in Children: A Systematic Review.Antibiotics 2021,
10, 912.
[18]Amanda L. Hurst, Christine Baumgartner, Christine
E. Experience with Continuous Infusion Vancomycin Dosing in
a Large Pediatric Hospital.Journal of the Pediatric Infectious
Diseases Society.2019 ,8(2):174-179.
[19]Emma Wysocki, PharmD , Jessica Tansmore, PharmD.
When There Is No Trough: Use and Outcomes of Continuous-
Infusion Vancomycin at a Free-Standing Children’s Hospital.J
Pediatr Pharmacol Ther .2022 ,27 (5) :452-456
[20] 翟所迪，贺蓓，等 . 中国万古霉素治疗药物监测指
南 . 中国临床药理学杂志 .2016.32(17).
[21]Heather L. Girand, PharmD.Continuous Infusion
Vancomycin in Pediatric Patients: A Critical Review of the
Evidence.J Pediatr Pharmacol Ther 2020;25(3):198–214.
[22]Paola Costenaro , Chiara Minotti ，Optimizing
Antibiotic Treatment Strategies for Neonates and Children:
Does Implementing Extended or Prolonged Infusion Provide any
Advantage? Antibiotics 2020, 9, 329.
[23]Cardile, A.P., Tan, C., Lustik, M.B. et al. Optimization
of time to initial vancomycin target trough improves clinical
outcomes.SpringerPlus4,364(2015).
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