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肠道菌群与代谢组学在心血管疾病研究中的新进展

蔡 艳梅, 周 健*

摘要

肠道菌群失调与多种心血管疾病密切相关,肠道菌群失衡会导致其代谢产物异常,进而加剧心血管疾病的发生发展。
代谢组学技术通过高通量测序和数据分析对生物体液内的代谢物进行定性定量分析,发现生物标志物并帮助阐明疾病的发
生机制,为疾病的早期诊断 / 预防及治疗提供新思路。在本篇综述中主要阐述应用代谢组学技术对肠道菌群及其代谢产物
进行定性定量分析,讨论可能与心血管疾病发生发展相关的相关代谢产物及菌群及其可能的发生机制,综合整理肠道菌与
代谢组学在心血管疾病研究的新进展。

关键词

肠道菌群;心血管疾病;代谢组学;微生物

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参考

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