非编码 RNA 在肝脏疾病中的应用前景和现状
摘要
RNA（lncRNA），它们在肝病发病机制中发挥着至关重要的作用。这篇综述探讨了 circRNA 在肝脏病理学中的各种功能，
包括代谢相关性脂肪肝、肝细胞癌、酒精相关性肝病以及胆管疾病（如原发性硬化性胆管炎和胆管癌）。我们重点介绍了
调控肝脏脂质代谢、炎症、纤维化和肿瘤发生的关键非编码 RNA，展示了它们的诊断和治疗潜力。新出现的基于 RNA 的
疗法，如 mRNA 疗法、RNA 干扰和反义寡核苷酸，提供了调节 circRNA 活性和在分子水平上治疗肝病的方法。同时，测
序技术和生物信息学管道的进步也使新型 circRNA 的鉴定和功能表征成为可能，从而推动了个性化医疗的创新。总之，本
综述强调了 circRNA 作为肝病生物标志物和治疗靶点的潜力，并强调了进一步研究其调控机制和临床应用的必要性。
关键词
全文:
PDF参考
[1] Errichelli L, Dini MS, Laneve P, et al. FUS affects
circular RNA expression in murine embryonic stem cell-derived
motor neurons. Nat Commun. 2017 Mar 30 2017;8:14741.
[2] Kokot KE, Kneuer JM, John D, et al. Reduction of A-to-I
RNA editing in the failing human heart regulates formation of
circular RNAs. Basic Res Cardiol. 2022 Jun 23 2022;117(1):32.
[3] Pan T, Sun X, Liu Y, et al. Heat stress alters genome-
wide profiles of circular RNAs in Arabidopsis. Plant Mol Biol.
2018 Feb 2018;96(3):217-229.
[4] Liang D, Wilusz JE. Short intronic repeat sequences
facilitate circular RNA production. Genes Dev. 2014 Oct 15
2014;28(20):2233-2247.
[5] Legnini I, Di Timoteo G, Rossi F, et al. Circ-ZNF609
Is a Circular RNA that Can Be Translated and Functions in
Myogenesis. Mol Cell. 2017 Apr 6 2017;66(1):22-37.
[6] Bahadur S, Mukherjee PK, Milan AS, Kar A, Harwansh
RK, Pandit S. Metabolism-mediated interaction potential of
standardized extract of Tinospora cordifolia through rat and
human liver microsomes. Indian J Pharmacol. 2016 Sep-Oct
2016;48(5):576-581.
[7] Sayaf K, Gabbia D, Russo FP, De Martin S. The Role of
Sex in Acute and Chronic Liver Damage. Int J Mol Sci. 2022 Sep
13 2022;23(18).
[8] Connor F, Wright E, Denny P, Koopman P, Ashworth
A. The Sry-related HMG box-containing gene Sox6 is expressed
in the adult testis and developing nervous system of the mouse.
Nucleic Acids Res. 1995 Sep 11 1995;23(17):3365-3372.
[9] Tong Y, Zhang S, Riddle S, Song R, Yue D. Circular
RNAs in the Origin of Developmental Lung Disease: Promising
Diagnostic and Therapeutic Biomarkers. Biomolecules. 2023 Mar
15 2023;13(3).
[10] Gong S, Gaccioli F, Dopierala J, et al. The RNA
landscape of the human placenta in health and disease. Nat
Commun. 2021 May 11 2021;12(1):2639.
[11] Conn VM, Chinnaiyan AM, Conn SJ. Circular RNA in
cancer. Nat Rev Cancer. 2024 Sep 2024;24(9):597-613.
[12] Hackstein CP. Liver damage and immune responses. Z
Gastroenterol. 2025 Jan 2025;63(1):56-64.
[13] Gillman R, Lopes FK, Wankell M, Hebbard L. The role
of DNA damage and repair in liver cancer. Biochim Biophys Acta
Rev Cancer. 2021 Jan 2021;1875(1):188493.
[14] Apelt K, White SM, Kim HS, et al. ERCC1 mutations
impede DNA damage repair and cause liver and kidney
dysfunction in patients. J Exp Med. 2021 Mar 1 2021;218(3).
[15] Lin J, Shi J, Guo H, et al. Alterations in DNA Damage
Repair Genes in Primary Liver Cancer. Clin Cancer Res. 2019
Aug 1 2019;25(15):4701-4711.
[16] Powell EE, Wong VW, Rinella M. Non-alcoholic fatty
liver disease. Lancet. 2021 Jun 5 2021;397(10290):2212-2224.
[17] Lefebvre P, Staels B. Hepatic sexual dimorphism
- implications for non-alcoholic fatty liver disease. Nat Rev
Endocrinol. 2021 Nov 2021;17(11):662-670.
[18] Mitten EK, Baffy G. Mechanotransduction in the
pathogenesis of non-alcoholic fatty liver disease. J Hepatol. 2022
Dec 2022;77(6):1642-1656.
[19] Demir M, Lang S, Hartmann P, et al. The fecal
mycobiome in non-alcoholic fatty liver disease. J Hepatol. 2022
Apr 2022;76(4):788-799.
[20] Guo XY, Chen JN, Sun F, Wang YQ, Pan Q, Fan JG.
circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation:
An Inhibitory Role against Hepatic Steatosis. Oxid Med Cell
Longev. 一月 -01 2017;2017:3960197.
[21] Chen R, Wang SK, Belk JA, et al. Engineering circular
RNA for enhanced protein production. Nat Biotechnol. 2023 Feb
2023;41(2):262-272.
[22] Zhang L, Wang Z. Circular RNA hsa_circ_0004812
impairs IFN-induced immune response by sponging miR-1287-
5p to regulate FSTL1 in chronic hepatitis B. Virol J. 2020 Mar 18
2020;17(1):40.
[23] Honda M, Kaneko S, Kawai H, Shirota Y, Kobayashi K.
Differential gene expression between chronic hepatitis B and C
hepatic lesion. Gastroenterology. 2001 Mar 2001;120(4):955-966.
[24] Sarnow P, Sagan SM. Unraveling the Mysterious
Interactions Between Hepatitis C Virus RNA and Liver-Specific
MicroRNA-122. Annu Rev Virol. 2016 Sep 29 2016;3(1):309-
332.
[25] Kunden RD, Khan JQ, Ghezelbash S, Wilson JA. The
Role of the Liver-Specific microRNA, miRNA-122 in the HCV
Replication Cycle. Int J Mol Sci. 2020 Aug 7 2020;21(16).
[26] Chen TC, Tallo-Parra M, Cao QM, et al. Host-derived
circular RNAs display proviral activities in Hepatitis C virus-
infected cells. PLoS Pathog. 2020 Aug 2020;16(8):e1008346.
[27] Sekiba K, Otsuka M, Ohno M, et al. DHX9 regulates
production of hepatitis B virus-derived circular RNA and viral
protein levels. Oncotarget. 2018 Apr 20 2018;9(30):20953-20964.
[28] Carbone M, Neuberger JM. Autoimmune liver disease,
autoimmunity and liver transplantation. J Hepatol. 2014 Jan
2014;60(1):210-223.
[29] Zheng J, Li Z, Wang T, Zhao Y, Wang Y. Microarray
Expression Profile of Circular RNAs in Plasma from Primary
Biliary Cholangitis Patients. Cell Physiol Biochem. 一 月 -01
2017;44(4):1271-1281.
[30] Liu Y, Li Z, Hao J, Chen H, Hou T, Hao H. Circular
RNAs associated with a mouse model of concanavalin A-induced
autoimmune hepatitis: preliminary screening and comprehensive
functional analysis. FEBS Open Bio. 2020 Nov 2020;10(11):2350-
2362.
[31] V o g e l A , M e y e r T , S a p i s o c h i n G , S a l e m R ,
Saborowski A. Hepatocellular carcinoma. Lancet. 2022 Oct 15
2022;400(10360):1345-1362.
[32] Abitbol S, Dahmani R, Coulouarn C, et al. AXIN
deficiency in human and mouse hepatocytes induces hepatocellular
carcinoma in the absence of beta-catenin activation. J Hepatol.
2018 Jun 2018;68(6):1203-1213.
[33] Zhang Y, Liu H, Li W, et al. CircRNA_100269 is
downregulated in gastric cancer and suppresses tumor cell
growth by targeting miR-630. Aging (Albany NY). 2017 Jun 27
2017;9(6):1585-1594.
[34] Geng HH, Li R, Su YM, et al. The Circular RNA Cdr1as
Promotes Myocardial Infarction by Mediating the Regulation of
miR-7a on Its Target Genes Expression. PLoS One. 一 月 -01
2016;11(3):e151753.
[35] 林培艺 , 翁明哲 , 汤朝晖 . 长链非编码 RNA 在肝脏
疾病中的研究进展 [J]. 第二军医大学学报 ,2013,34(03):322-
327.
[36] Li P, Chen S, Chen H, et al. Using circular RNA as a
novel type of biomarker in the screening of gastric cancer. Clin
Chim Acta. 2015 Apr 15 2015;444:132-136.
[37] Fu L, Yao T, Chen Q, Mo X, Hu Y, Guo J. Screening
differential circular RNA expression profiles reveals hsa_
circ_0004018 is associated with hepatocellular carcinoma.
Oncotarget. 2017 Aug 29 2017;8(35):58405-58416.
[38] Xu Y, Yao Y, Zhong X, et al. Downregulated circular
RNA hsa_circ_0001649 regulates proliferation, migration and
invasion in cholangiocarcinoma cells. Biochem Biophys Res
Commun. 2018 Feb 5 2018;496(2):455-461.
(17 摘要 Views, 24 PDF Downloads)
Refbacks
- 当前没有refback。