非编码 RNA 在肝脏疾病中的应用前景和现状
摘要
RNA（lncRNA），它们在肝病发病机制中发挥着至关重要的作用。这篇综述探讨了 circRNA 在肝脏病理学中的各种功能，
包括代谢相关性脂肪肝、肝细胞癌、酒精相关性肝病以及胆管疾病（如原发性硬化性胆管炎和胆管癌）。我们重点介绍了
调控肝脏脂质代谢、炎症、纤维化和肿瘤发生的关键非编码 RNA，展示了它们的诊断和治疗潜力。新出现的基于 RNA 的
疗法，如 mRNA 疗法、RNA 干扰和反义寡核苷酸，提供了调节 circRNA 活性和在分子水平上治疗肝病的方法。同时，测
序技术和生物信息学管道的进步也使新型 circRNA 的鉴定和功能表征成为可能，从而推动了个性化医疗的创新。总之，本
综述强调了 circRNA 作为肝病生物标志物和治疗靶点的潜力，并强调了进一步研究其调控机制和临床应用的必要性。
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