基于宫颈癌预后模型及免疫浸润分析寻找宫颈癌预后标志物的研究
摘要
标志物。方法 利用 TCGA 及 GEO 公共数据库进行宫颈癌预后基因的筛选、建立模型并进行验证，通过免疫浸润分析研究
预后表达差异基因与肿瘤免疫微环境的相互关系。结果 SPP1 作为宫颈癌预后表达基因之一，其高表达与较差的宫颈癌预
后相关，在肿瘤免疫微环境中，与 M0 型巨噬细胞的浸润相关；IL3RA 的表达则提示了较好的宫颈癌预后，其在肿瘤免疫
微环境中的表达与 CD8+T 细胞的浸润相关。结论 寻找宫颈癌预后相关标志物，并研究其在宫颈癌发生发展中的作用，对
个体化精准治疗宫颈癌意义重大。
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