p16INK4a 及其与宫颈癌前疾病关系的研究现状
摘要
p16INK4a 是一种 CDK4/CDK6 抑制因子，通过影响 Rb 通路进而抑制细胞 DNA 合成，在细胞周期调控中有重要意义。本
文就 P16INK4a 的结构、功能及其与宫颈癌前疾病关系做一综述。
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[1] World Health Organization. Global strategy to accelerate
the elimination of cervical cancer as a public health problem
[EB/OL]. [2020.11.17]. https://www.who.int/publications/i/
item/9789240014107.
[2] Serrano M, Hannon GJ, Beach D. A new regulatory motif
in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Nature. 1993 Dec 16;366(6456):704-707.
[3] Kamb A, Gruis NA, Weaver-Feldhaus J, et al. A cell
cycle regulator potentially involved in genesis of many tumor
types. Science. 1994 Apr 15;264(5157):436-440.
[4] Guo T, Chai X, Liu Q, et al. Downregulation of P16
promotes cigarette smoke extract-induced vascular smooth muscle
cell proliferation via preventing G1/S phase transition. Exp Ther
Med. 2017 Jul;14(1):214-220.
[5] Tam SW, Shay JW, Pagano M. Differential expression and
cell cycle regulation of the cyclin-dependent kinase 4 inhibitor
p16Ink4. Cancer Res. 1994 Nov 15;54(22):5816-5820.
[6] 兰晓卉 , 杨琦 , 邹颖刚 , 等 . p16INK4a 免疫细胞化学
染色对不同基因型 HPV 感染者的分流价值 [J]. 吉林大学 学
报（医学版）,2021,47(2):421-429.
[7] Koliopoulos G, Nyaga VN, Santesso N, et al. Cytology
versus HPV testing for cervical cancer screening in the
general population. Cochrane Database Syst Rev. 2017 Aug
10;8(8):CD008587.
[8] Tsoumpou I, Arbyn M, Kyrgiou M, et al. p16(INK4a)
immunostaining in cytological and histological specimens from
the uterine cervix: a systematic review and meta-analysis. Cancer
Treat Rev. 2009 May;35(3):210-220.
[9] 叶洪楠 , 游珂 , 郭艳利 , 等 . P16INK4a 及 Ki-67 免疫
细胞化学检测对 ASC-US 中高级别病变检出的意义 [J]. 肿瘤
预防与治疗 ,2014,27(1):6-11.
[10] Gustafsson L, Adami HO. Natural history of cervical
neoplasia: consistent results obtained by an identification
technique. Br J Cancer. 1989 Jul;60(1):132-141.
[11] Zuberi Z, Mremi A, Chilongola JO, et al. Expression
analysis of p16 and TOP2A protein biomarkers in cervical cancer
lesions and their correlation with clinico-histopathological
characteristics in a referral hospital, Tanzania. PLoS One. 2021
Oct 27;16(10): e0259096.
[12] Zhao F, Ma D, Wang T, et al. The Application of Liquid-
Based Cytological Detection for P16, Cytologic Evaluation and
High-Risk Human Papillomavirus Testing in Cervical Cancer
Screening: A Clinical Evaluation. Int J Womens Health. 2022 Jul
28; 14:965-973.
[13] Wright Thomas C, Stoler Mark H, Ferenczy
Alex, et al. The CERTAIN Study Results: Adjunctive p16
Immunohistochemistry Use in Cervical Biopsies According
to LAST Criteria. The American journal of surgical
pathology,2021,45(10).
[14] 黄丽萍 , 林霞 .P16 蛋白表达在分流宫颈上皮内瘤变
Ⅱ中的临床意义 [J]. 中国医药导报 ,2018,15(02):83-86.
[15] 刘静云 , 吕志红 , 徐芳 , 等 . 微管蛋白及 P16 蛋白在
宫颈上皮内瘤变Ⅱ～Ⅲ级患者宫颈环形电切术后复发预测
模型的应用分析 . 中国医学装备 ,2022,19(6):101-105.
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