孕晚期母体血清维生素 D 水平与妊娠结局之间的相关性分析
摘要
1 月至 2023 年 6 月于中国医科大学附属第四医院住院分娩并进行 Vit D 检测的孕妇，孕晚期妇女 25（OH）D 水平均采
用高效液相色谱串联质谱法测定，根据结果分为：Vit D 充足组（25（OH）D ≥ 30ng/mL）、不足组（30ng/mL ＞ 25
（OH）D ≥ 20ng/mL）和缺乏组（25（OH）D ＜ 20ng/mL），采用二元 Logistic 回归探讨妊娠晚期母体 Vit D 水平与妊
娠结局的相关性。结果：妊娠晚期孕妇 Vit D 缺乏非常普遍，Vit D 平均水平为 16.18±8.03ng/mL，大约 71.02% 的孕妇
Vit D 缺乏，仅 6.87% 的孕妇 Vit D 浓度达到充足水平。Vit D 缺乏组孕妇的尿路感染患病率高于充足组，差异有统计学
意义（Pbonferroni=0.018）。Vit D 缺乏组孕妇的剖宫产率高于充足组及不足组，差异有统计学意义（缺乏组 vs 充足组：
Pbonferroni=0.004，缺乏组 vs 不足组：Pbonferroni=0.016）。Vit D 缺乏组孕妇妊娠晚期贫血的发生率明显高于不足组、充
足组，差异有统计学意义（缺乏组 vs 不足组：Pbonferroni ＜ 0.001，缺乏组 vs 充足组：Pbonferroni ＜ 0.001）。结论：本研
究发现妊娠晚期孕妇 Vit D 缺乏较为普遍，妊娠晚期 Vit D 缺乏与尿路感染、剖宫产、贫血的发生有关。
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