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中药复方用于阿霉素心脏毒性防治的研究进展

谢 穗芬

摘要

阿霉素(Dox)是一种广泛使用的抗癌药物,但其心脏毒性限制了其临床应用。中药复方因其整体观念、辩证施治、
多组分协同作用等特点,在防治阿霉素心脏毒性(DIC)方面显示出潜力。本文综述了多种中药复方的组成、出处和防治机制,
如参麦注射液、参附汤、柴胡三参胶囊、芪参颗粒、芪苈强心胶囊、芪附汤、益气活血方等,它们通过抗氧化应激、抗炎、
抗凋亡、保护线粒体功能等机制,减轻心肌损伤并改善心脏功能。特别指出,人参和黄芪是应用最广泛的两味中药,它们
在心脏保护中起着关键作用。尽管中药复方在防治 DIC 方面取得了进展,但仍面临成分复杂导致机制研究难以深入、质量
控制、安全性评估等挑战。未来的研究需要深入探讨中药复方的作用机制,并确保其安全性和有效性。

关键词

中药复方;阿霉素;心脏毒性防治;机制研究

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