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PCSK9 抑制剂在心血管疾病领域外的研究进展

邹 爽, 杨 婷, 宋 红飞, 熊 攀, 李 岸舟, 孟 永*

摘要

近年来,PCSK9 抑制剂因其在降低低密度脂蛋白胆固醇(LDL-C)方面的显著效果不仅在心血管疾病的治疗中取
得了重要进展,还展现出在其他疾病领域的应用潜力。研究表明,PCSK9 抑制剂在代谢疾病、神经系统疾病、免疫性疾病、
肿瘤、感染等领域展现出良好的前景。尽管这些研究取得阶段成就,但面临着许多挑战,如缺乏大规模临床试验的数据支持、
不同疾病模型下的作用机制尚不明确等。本文旨在综述 PCSK9 抑制剂在心血管领域外的研究进展,探讨其潜在的机制与临
床意义,以期为未来的研究方向提供新的视角和思路。

关键词

PCSK9 抑制剂;代谢疾病;神经系统疾病;免疫性疾病;肿瘤

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参考

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