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病毒的免疫逃逸

何 鑫妍

摘要

自然界的病毒一直是威胁人类健康的存在,按照病毒携带的基因可以分为 DNA 病毒和 RNA 病毒。而应对病毒入
侵的主要防线是人体自身免疫系统。在这其中能够识别病毒核酸的模式识别受体和感受器发挥着极为重要的作用。在漫长
的斗争中,各类病毒也进化出了具有特点的免疫逃逸的特性。本篇综述主要讲述了一些病毒免疫逃逸的方式。

关键词

免疫逃逸;模式识别受体;TLR;cGAS-STING

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参考

[1] TAKEUCHI O, AKIRA S. Pattern recognition receptors

and inflammation [J]. Cell, 2010, 140(6): 805-20.

[2] WU J, CHEN Z J. Innate immune sensing and signaling

of cytosolic nucleic acids [J]. Annu Rev Immunol, 2014, 32: 461-

88.

[3] KUMAGAI Y, AKIRA S. Identification and functions of

pattern-recognition receptors [J]. J Allergy Clin Immunol, 2010,

125(5): 985-92.

[4] LOO Y M, GALE M, JR. Immune signaling by RIG-I-

like receptors [J]. Immunity, 2011, 34(5): 680-92.

[5] KIKKERT M. Innate Immune Evasion by Human

Respiratory RNA Viruses [J]. J Innate Immun, 2020, 12(1): 4-20.

[6] PETROVA V N, RUSSELL C A. The evolution of

seasonal influenza viruses [J]. Nat Rev Microbiol, 2018, 16(1): 47-

60.

[7] XIAOJUN TAN, 2, LIJUN SUN,1,2,3, JUEQI CHEN,1,2

AND ZHIJIAN J. CHEN1,2,3. Detection of Microbial Infections

Through Innate Immune Sensing of Nucleic Acids [J]. Annu Rev

Microbiol 2018.

[8] MA Z, DAMANIA B. The cGAS-STING Defense

Pathway and Its Counteraction by Viruses [J]. Cell Host Microbe,

2016, 19(2): 150-8.


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