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化疗所致周围神经病变的机制与治疗

周 晓波, 曹潇 月*

摘要

大约 20-40% 接受神经毒性药物相关化疗 ( 如紫杉烷、铂类、长春花生物碱、硼替佐米 ) 的肿瘤患者会出现由化疗
药物化疗引起的周围神经病变,被称为化疗相关性周围神经病变(chemotherapy-induced peripheral neuropathy, CIPN),其
中典型的临床症状之一即为疼痛。CIPN 导致等疼痛在化疗过程中即可出现,可在化疗结束后仍持续相当长的一段时间,
对器官功能和生活质量有持续且长久的负面影响。目前已有相当多的研究致力于寻找预防或治疗 CIPN 的方法,本文总结
了近年的相关研究,以期为临床实践提供帮助。

关键词

化疗;周围神经病变;疼痛;度洛西汀;普瑞巴林;神经节苷脂

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参考

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