外泌体在膀胱癌中作用的研究进展
摘要
等三种方式实现信息的交流与传递，形成一种全新的细胞间交流系统。膀胱癌来源的外泌体在膀胱癌发生、侵袭迁移、诱导
耐药和免疫逃逸等过程中发挥着重要作用。本文综述了外泌体的主要生物学特征以及其在膀胱癌进展与诊疗方面的新进展。
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[1]SIEGEL R L, MILLER K D, JEMAL A. Cancer statistics,
2020 [J]. Ca-cancer j clin, 2020, 70(1): 7-30.
[2]HARDING C V, HEUSER J E, STAHL P D. Exosomes:
looking back three decades and into the future [J]. J cell biol,
2013, 200(4): 367-71.
[3]WORTZEL I, DROR S, KENIFIC C M, LYDEN D.
Exosome-Mediated Metastasis: Communication from a Distance
[J]. Dev cell, 2019, 49(3): 347-60.
[4]SHAO H, IM H, CASTRO C M, et al. New Technologies
for Analysis of Extracellular Vesicles [J]. Chem rev, 2018, 118(4):
1917-50.
[5]LEE Y, EL ANDALOUSSI S, WOOD M J. Exosomes
and microvesicles: extracellular vesicles for genetic information
transfer and gene therapy [J]. Hum mol genet, 2012, 21(R1):
R125-34.
[6] 刘维辉 , 陈俊毅 , 李毅宁 , 朱绍兴 . 外泌体应用于膀
胱癌诊疗的基础与临床研究进展 [J]. 中国肿瘤 , 2019, 28(01):
50-4.
[7]GOULET C R, CHAMPAGNE A, BERNARD G, et al.
Cancer-associated fibroblasts induce epithelial-mesenchymal
transition of bladder cancer cells through paracrine IL-6 signalling
[J]. BMC Cancer, 2019, 19(1): 137.
[8]BERRONDO C, FLAX J, KUCHEROV V, et al.
Expression of the Long Non-Coding RNA HOTAIR Correlates
with Disease Progression in Bladder Cancer and Is Contained in
Bladder Cancer Patient Urinary Exosomes [J]. PLoS One, 2016,
11(1): e0147236.
[9]HUANG C S, HO J Y, CHIANG J H, et al. Exosome-
Derived LINC00960 and LINC02470 Promote the Epithelial-
Mesenchymal Transition and Aggressiveness of Bladder Cancer
Cells [J]. Cells, 2020, 9(6): null.
[10] K U M A R A , D E E P G . H y p o x i a i n t u m o r
microenvironment regulates exosome biogenesis: Molecular
mechanisms and translational opportunities [J]. Cancer lett, 2020,
479(null): 23-30.
[11]XUE M, CHEN W, XIANG A, et al. Hypoxic exosomes
facilitate bladder tumor growth and development through
transferring long non-coding RNA-UCA1 [J]. Mol Cancer, 2017,
16(1): 143.
[12]BECKHAM C J, OLSEN J, YIN P N, et al. Bladder
cancer exosomes contain EDIL-3/Del1 and facilitate cancer
progression [J]. J urology, 2014, 192(2): 583-92.
[13]ANDREU Z, OTTA OSHIRO R, REDRUELLO A, et al.
Extracellular vesicles as a source for non-invasive biomarkers in
bladder cancer progression [J]. Eur j pharm sci, 2017, 98(null):
70-9.
[14]BAIG M S, ROY A, RAJPOOT S, et al. Tumor-derived
exosomes in the regulation of macrophage polarization [J]. Inflamm
res, 2020, 69(5): 435-51.
[15]ALLAN D, TIEU A, LALU M, BURGER D. Mesenchymal
stromal cell-derived extracellular vesicles for regenerative therapy
and immune modulation: Progress and challenges toward clinical
application [J]. Stem cell transl med, 2020, 9(1): 39-46.
[16]CLAYTON A, MITCHELL J P, COURT J, et al. Human
tumor-derived exosomes down-modulate NKG2D expression [J]. J
immunol, 2008, 180(11): 7249-58.
[17]LI C, DU Y, YANG Z, et al. GALNT1-Mediated
Glycosylation and Activation of Sonic Hedgehog Signaling
Maintains the Self-Renewal and Tumor-Initiating Capacity of
Bladder Cancer Stem Cells [J]. Cancer res, 2016, 76(5): 1273-83.
[18]ZHENG R, DU M, WANG X, et al. Exosome-transmitted
long non-coding RNA PTENP1 suppresses bladder cancer
progression [J]. Mol Cancer, 2018, 17(1): 143.
[19]WANG L, SKOTLAND T, BERGE V, et al. Exosomal
proteins as prostate cancer biomarkers in urine: From mass
spectrometry discovery to immunoassay-based validation [J]. Eur j
pharm sci, 2017, 98(null): 80-5.
[20]ZHAN Y, DU L, WANG L, et al. Expression signatures
of exosomal long non-coding RNAs in urine serve as novel non-
invasive biomarkers for diagnosis and recurrence prediction of
bladder cancer [J]. Mol Cancer, 2018, 17(1): 142.
[21] 崔琦 , 许学文 , 杨文娟 , et al. 膀胱癌组织及尿液外
泌体中 NTN1 的表达与膀胱癌恶性程度的相关性研究 [J]. 解
剖科学进展 , 2024, 30(04): 337-40+44.
[22]LIAO W, DU Y, ZHANG C, et al. Exosomes: The next
generation of endogenous nanomaterials for advanced drug
delivery and therapy [J]. Acta biomater, 2019, 86(null): 1-14.
[23]GRECO K A, FRANZEN C A, FOREMAN K E, et al.
PLK-1 Silencing in Bladder Cancer by siRNA Delivered With
Exosomes [J]. Urology, 2016, 91(null): 241.e1-7.
[24]CAI H, YANG X, GAO Y, et al. Exosomal MicroRNA-
9-3p Secreted from BMSCs Downregulates ESM1 to Suppress
the Development of Bladder Cancer [J]. Mol Ther Nucleic Acids,
2019, 18(null): 787-800.
[25]LIU H, CHEN L, PENG Y, et al. Dendritic cells loaded
with tumor derived exosomes for cancer immunotherapy [J].
Oncotarget, 2018, 9(2): 2887-94.
[26]ZHANG J, ZHANG Y, LUO C, et al. Glycosylphosphatidylinositol-anchored interleukin-2 expressed on tumorderived exosomes induces antitumor immune response in vitro [J].
Tumori j, 2010, 96(3): 452-9.
[27]INGATO D, EDSON J A, ZAKHARIAN M, KWON Y
J. Cancer Cell-Derived, Drug-Loaded Nanovesicles Induced by
Sulfhydryl-Blocking for Effective and Safe Cancer Therapy [J].
Acs nano, 2018, 12(9): 9568-77.
[28] 李思迪 , 侯信 , 亓洪昭 , et al. 外泌体 : 为高效药物
投递策略提供天然的内源性纳米载体 [J]. 化学进展 , 2016,
28(Z2): 353-62.
[29]FAIS S, LOGOZZI M, LUGINI L, et al. Exosomes: the
ideal nanovectors for biodelivery [J]. Biol chem, 2013, 394(1):
1-15.
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