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浓缩生长因子在口腔种植领域的应用进展

王  喻

摘要

口腔种植术已成为牙齿缺失的最好修复方式之一,但是种植体周围软硬组织的缺损,种植术后并发症的发生都可
降低种植成功率。为提高种植成功率,目前使用的方法有人工骨填充、机械清创、化学治疗等,但效果欠佳、费用昂贵等
迫切希望低廉、高效的方式出现。而浓缩生长因子(concentrate growth factors,CGF)属血小板衍生物,有容易制备,无排
斥性,能够促进软硬组织再生等优点使其在口腔种植方面有重大意义。

关键词

浓缩生长因子;口腔种植;组织再生

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参考

[1] 陆英 , 王似鋆 , 邹多宏 . 浓缩生长因子在口腔组

织再生工程中的应用研究新进展 [J]. 中国医学科学院学

报 ,2023,45(03):500-505.

[2] 梁 荣 洲 , 杨 思 奋 . 浓 缩 生 长 因 子 在 皮 肤 和 整 形 美

容 中 的 应 用 进 展 [J]. 中 国 美 容 医 学 ,2024,33(11):175-178.

DOI:10.15909/j.cnki.cn61-1347/r.006577.

[3]Xuelai Y ,Huan S ,Poh E H , et al.Effect of Concentrated

Growth Factor on Distraction Osteogenesis of Dental Implant

Distractors.[J].Journal of oral and maxillofacial surgery : official

journal of the American Association of Oral and Maxillofacial

Surgeons,2022,80(5):889-896.

[4]Keiko O ,Arafat M K ,Bowen Z , et al.Human Fresh Fibrin

Membrane with Bone Morphogenetic Protein-2 (BMP-2) Induces

Bone Formation in the Subcutaneous Tissues of Nude Mice[J].

Materials,2020,14(1):150-150.

[5]Eitan M ,Drora H A ,Oren P , et al.Use of PRP, PRF and

CGF in Periodontal Regeneration and Facial Rejuvenation—A

Narrative Review[J].Biology,2021,10(4):317-317.

[6]Syafiq M A ,Mohd N Y ,Sufinah A A , et al.Preliminary

Novel Analysis on Antimicrobial Properties of Concentrated

Growth Factor against Bacteria-Induced Oral Diseases.[J].

European journal of dentistry,2022,16(4):

[7]Ramtin C ,Masoumeh F ,Mehrnoosh S , et al.Evaluation

of antibacterial effect of concentrated growth factor on

Aggregatibacter actinomycetemcomitans and Porphyromonas

gingivalis[J].Journal of Family Medicine and Primary

Care,2022,11(6):2865-2869.

[8]Eleonora S ,Nadia C ,Laura G , et al.Analysis

of CGF Biomolecules, Structure and Cell Population:

Characterization of the Stemness Features of CGF Cells and

Osteogenic Potential[J].International Journal of Molecular

Sciences,2021,22(16):8867-8867.

[9]Aghamohamadi Z ,Kadkhodazadeh M ,Torshabi M , et al.A

compound of concentrated growth factor and periodontal ligament

stem cell-derived conditioned medium[J].Tissue and Cell,2020,65

(prepublish):101373-101373.

[10] 玛衣努尔·艾赛提 , 马依热·阿布都赛麦提 , 热孜

亚·艾尼 , 等 . 浓缩自体生长因子对牙周组织再生术用于

重度牙周炎患者疗效,牙龈厚度和免疫因子水平影响分析

[J]. 现代生物医学进展 ,2024,24(12):2288-2292.DOI:10.13241/

j.cnki.pmb.2024.12.016.

[11]Lei Q ,Lu L ,Yue H , et al.Concentrated growth factor

promotes gingival regeneration through the AKT/Wnt/β-catenin

and YAP signaling pathways.[J].Artificial cells, nanomedicine, and

biotechnology,2020,48(1):920-932.

[12]Wenjing L ,Feifei W ,Fusheng D , et al.CGF Membrane

Promotes Periodontal Tissue Regeneration Mediated by hUCMSCs

through Upregulating TAZ and Osteogenic Differentiation

Genes[J].Stem Cells International,2021,20216644366-6644366.

[13]Kai D ,WenJuan Z ,ZhongHao L , et al.The extract

of concentrated growth factor enhances osteogenic activity

of osteoblast through PI3K/AKT pathway and promotes

bone regeneration in vivo.[J].International journal of implant

dentistry,2021,7(1):70-70.

[14]Sema K ,Cüneyt Z K ,Vakur O .The Effect of

Concentrated Growth Factor on Calvarial Bone in Diabetic Healing.

[J].The Journal of craniofacial surgery,2020,31(1):158-161.

[15]Shoufu S ,Xiaodong X ,Zhongxiao Z , et al.A novel

concentrated growth factor (CGF) and bio-oss based strategy for

second molar protection after impacted mandibular third molar

extraction: a randomized controlled clinical study[J].BMC Oral

Health,2023,23(1):750-750.

[16]Ahmed S E ,Xiang L ,Ahmed K S , et al.Effect of

concentrated growth factor (CGF) on postoperative sequel of

completely impacted lower third molar extraction: a randomized

controlled clinical study[J].BMC Oral Health,2022,22(1):368-368.

[17]Dongdong F ,Dan L ,Chengjing L , et al.Efficacy and

Safety of Concentrated Growth Factor Fibrin on the Extraction of

Mandibular Third Molars: A Prospective, Randomized, Double-

Blind Controlled Clinical Study.[J].Journal of oral and maxillofacial

surgery : official journal of the American Association of Oral and

Maxillofacial Surgeons,2021,80(4):700-708.

[18]Keranmu D, Nuermuhanmode N, Ainiwaer A, et al.

Clinical application of concentrate growth factors combined with

bone substitute in Alveolar ridge preservation of anterior teeth[J].

BMC Oral Health, 2022, 22(1):1-9.DOI:10.1186/s12903-022-

02091-8.

[19]S. R K ,Prabhu R A ,Nesappan T , et al.Effectiveness

of Concentrated Growth Factor on Surgical Wound Healing:

A Pilot Study[J].Journal of Long-Term Effects of Medical

Implants,2021,31(3):27-32.

[20] 常颖 , 赵宁 , 杨文朋 , 等 . 浓缩生长因子联合 Bio-

Oss 骨粉在拔牙后牙槽嵴保存中的应用效果 [J]. 口腔颌面

修 复 学 杂 志 ,2024,25(06):428-433+467.DOI:10.19748/j.cn.

kqxf.1009-3761.2024.6.005.

[21]Liang C ,Jing C ,Yu C , et al.Efficacy of concentrated

growth factor (CGF) in the surgical treatment of oral diseases:

a systematic review and meta-analysis.[J].BMC oral

health,2023,23(1):712-712.

[22]Krishnakumar D ,Mahendra J ,Ari G , et al.A clinical

and histological evaluation of platelet-rich fibrin and CGF for root

coverage procedure using coronally advanced flap: A split-mouth

design[J].Indian Journal of Dental Research,2019,30(6):970-974.

[23]Kaan T ,Bozkurt D ,Umut B , et al.Growth factor

membranes in treatment of multiple gingival recessions: a

randomized clinical trial.[J].Quintessence international (Berlin,

Germany : 1985),2021,0(0):12-11.

[24]Alessandro L ,Gaia F ,Paolo C , et al.Concentrated

Growth Factors (CGF) Combined with Melatonin in Guided

Bone Regeneration (GBR): A Case Report[J].Diagnosti

cs,2022,12(5):1257-1257.

[25] 夏岩 , 徐培 , 黄琛琛 , 等 . 单独应用浓缩生长因子

进行上颌窦内提升并同期种植的临床观察 [J]. 安徽医专学

报 ,2021,20(06):38-41.

[26]Eitan M ,Drora H A ,Roni K , et al.Autologous Platelet

Concentrates (APCs) for Hard Tissue Regeneration in Oral

Implantology, Sinus Floor Elevation, Peri-Implantitis, Socket

Preservation, and Medication-Related Osteonecrosis of the Jaw

(MRONJ): A Literature Review[J].Biology,2022,11(9):1254-1254.

[27]Sitamahalakshmi K ,Bingi K S ,Kumar K G , et

al.Rejuvenation of bone volume with CGF and i-PRF in intra-

osseous defects.[J].Bioinformation,2024,20(1):85-90.

[28]Jue C ,Lin C ,LingWei K , et al.Clinical observation of

Porcine Collagen Membrane + artificial Bovine Bone Granules

Guided tissue regeneration combined with Autologous CGF in the

treatment of severe periodontitis bone defect.[J].Pakistan journal of

medical sciences,2023,39(3):710-714.

[29]Xianli W ,Guoqing W ,Xibo Z , et al.Short-Term

Evaluation of Guided Bone Reconstruction with Titanium Mesh

Membranes and CGF Membranes in Immediate Implantation

of Anterior Maxillary Tooth[J].BioMed Research Internation

al,2021,20214754078-4754078.

[30]Yu X ,Yanyan Q ,Miao W , et al.Application of

sticky bone combined with concentrated growth factor

(CGF) for horizontal alveolar ridge augmentation of anterior

teeth: a randomized controlled clinical study[J].BMC Oral

Health,2024,24(1):431-431.

[31]N. M H ,J. S T .CGF-induced implant osteogenesis[J].

British Dental Journal,2024,236(7):507-507.

[32]Zhu Z ,Yang T ,Chen Q , et al.Concentrated growth factor

and collagen as barrier materials in alveolar ridge preservation for

posterior teeth: a prospective cohort study with one-year follow-

up.[J].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi

= West China journal of stomatology,2024,42(3):346-352.

[33]Vasudev B L ,Deeksha G ,Sarvesh R A , et al.The

use of concentrated growth factor in dental implantology:

A systematic review.[J].Journal of Indian Prosthodontic

Society,2020,20(1):3-10.

[34]Keranmu D, Ainiwaer A, Nuermuhanmode N, et al.

Application of concentrated growth factor to autotransplantation

w i t h i n f l a m m a t i o n i n r e c i p i e n t a r e a [ J ] . B M C O r a l

Health,2021,21(1). DOI:10.1186/s12903-021-01915-3.

[35]Lixia Y ,Jie L ,Lei Y , et al.Clinical Effect Evaluation of

Concentrated Growth Factor in Endodontic Microsurgery: A CrossSectional Study.[J].Journal of endodontics,2023,49(7):836-845.

[36]Ziling C ,Di M ,Le Z , et al.Efficacy of concentrated

growth factor with low-level laser for the regeneration of

interdental papilla defects.[J].Odontology,2022,110(4):1-10.

[37]LuZ ,BingquanH ,JunT , et al.Effectiveness of

concentrated growth factor and laser therapy on wound healing,

inferior alveolar nerve injury and periodontal bone defects post‐

mandibular impacted wisdom tooth extraction: A randomized

clinical trial[J].International Wound Journal,2024,21(1):e14651

-e14651.

[38]Jia XY, Jing SL, Sun Y, et al. A randomized controlled

clinical trial of concentrated growth factor combined with

sodium hyaluronate in the treatment of temporomandibular joint

osteoarthritis[J]. BMC Oral Health,2024,24(1). DOI:10.1186/

s12903-024-04258-x.

[39] 谢妮娜 , 魏路明 , 袁长永 , 等 . 浓缩生长因子和血

凝块作为支架在牙髓再生术中的疗效比较研究 [J]. 口腔医

学 ,2024,44(09):678-684.DOI:10.13591/j.cnki.kqyx.2024.09.007.

[40]Sijing Y ,Yi Z ,Qiang G , et al.Mechanism of

Pulp Regeneration Based on Concentrated Growth Factors

Regulating Cell Differentiation.[J].Bioengineering (Basel,

Switzerland),2023,10(5):


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