开放期刊系统

糖尿病对角膜影响的研究进展

徐 昕琦, 高 雯

摘要

随着糖尿病的患病率不断增加,近年来糖尿病性角膜病变受到广泛关注。慢性高血糖可改变角膜各层组织的形态、
代谢和生理,影响角膜角膜上皮、角膜神经、角膜内皮细胞及泪膜等结构,引起一系列角膜疾病。本文就糖尿病对角膜各
组织结构的影响进行综述,以期有助于临床诊疗。

关键词

糖尿病;角膜;并发症

全文:

PDF

参考

[1]Alberti KG, Zimmet PZ. Definition, diagnosis and

classification of diabetes mellitus and its complications. Part 1:

diagnosis and classification of diabetes mellitus provisional report

of a WHO consultation. Diabet Med. 1998 Jul;15(7):539-53.

[2] 钟学礼(执笔). 全国 14 省市 30 万人口中糖尿病调

查报告 [J]. 中华内科杂志 ,1981,20(11):678-683.

[3]Li Y, Teng D, Shi X, et al. Prevalence of diabetes

recorded in mainland China using 2018 diagnostic criteria from

the American Diabetes Association: national cross sectional study.

BMJ. 2020 Apr 28;369:m997.

[4]Ladea L, Zemba M, Calancea MI, et al. Corneal Epithelial

Changes in Diabetic Patients: A Review. Int J Mol Sci. 2024 Mar

19;25(6):3471.

[5]Markoulli M, Flanagan J, Tummanapalli SS, et al. The

impact of diabetes on corneal nerve morphology and ocular surface

integrity. Ocul Surf. 2018 Jan;16(1):45-57. Schultz RO, Peters

MA, Sobocinski K, et al. Diabetic corneal neuropathy. Trans Am

Ophthalmol Soc. 1983;81:107-24.

[6] Weng J, Ross C, Baker J,et al. Diabetes-Associated

Hyperglycemia Causes Rapid-Onset Ocular Surface Damage.

Invest Ophthalmol Vis Sci. 2023 Nov 1;64(14):11.

[7]Narooie-Noori F, Asharlous A, Mirzajani A, et al.

Comparison of anterior segment parameters of the eye between

type 2 diabetic with and without diabetic retinopathy and nondiabetic. Int J Ophthalmol. 2023 Apr 18;16(4):571-578.

[8]Wan L, Bai X, Zhou Q, et al. The advanced glycation endproducts (AGEs)/ROS/NLRP3 inflammasome axis contributes to

delayed diabetic corneal wound healing and nerve regeneration.

Int J Biol Sci. 2022 Jan 1;18(2):809-825.

[9] Yusufoğlu E, Güngör Kobat S, Keser S. Evaluation of

central corneal epithelial thickness with anterior segment OCT

in patients with type 2 diabetes mellitus. Int Ophthalmol. 2023

Jan;43(1):27-33.

[10] Saini JS, Khandalavla B. Corneal epithelial fragility

in diabetes mellitus. Can J Ophthalmol. 1995 Apr;30(3):142-6.

PMID: 7627899.

[11]Liu T, Sun DP, Li DF,et al. [Observation and

quantification of diabetic keratopathy in type 2 diabetes patients

using in vivo laser confocal microscopy]. Zhonghua Yan Ke Za

Zhi. 2020 Oct 11;56(10):754-760. Chinese.

[12]Dan J, Zhou QJ, Xie LX. [The research progress of

relationship between advanced glycation end products and diabetic

keratopathy]. Zhonghua Yan Ke Za Zhi. 2018 Jun 11;54(6):475-

480. Chinese.

[13]Gong J, Ding G, Hao Z,et al. Elucidating the mechanism

of corneal epithelial cell repair: unraveling the impact of growth

factors. Front Med (Lausanne). 2024 Apr 4;11:1384500.

[14] Kumar N, Pop-Busui R, Musch DC, et al. Central

Corneal Thickness Increase Due to Stromal Thickening With

Diabetic Peripheral Neuropathy Severity. Cornea. 2018

Sep;37(9):1138-1142.

[15] Ramm L, Spoerl E, Pillunat LE, et al. Is the Corneal

Thickness Profile Altered in Diabetes Mellitus? Curr Eye Res.

2020 Oct;45(10):1228-1234.

[16] 李秋玉 , 彭佳欣 , 邵毅 . 糖尿病对眼前节微环境平

衡的影响研究 [J]. 国际眼科杂志 ,2021,21(4):628-631.

[17]Cruzat A, Qazi Y, Hamrah P. In Vivo Confocal

Microscopy of Corneal Nerves in Health and Disease. Ocul Surf.

2017 Jan;15(1):15-47.

[18] Smith HS, Argoff CE. Pharmacological treatment of

diabetic neuropathic pain. Drugs. 2011 Mar 26;71(5):557-89.

[19]So WZ, Qi Wong NS, Tan HC, et al. Diabetic corneal

neuropathy as a surrogate marker for diabetic peripheral

neuropathy. Neural Regen Res. 2022 Oct;17(10):2172-2178.

[20] Cruzat A, Qazi Y, Hamrah P. In Vivo Confocal

Microscopy of Corneal Nerves in Health and Disease. Ocul Surf.

2017 Jan;15(1):15-47.

[21]Ziegler D, Papanas N, Zhivov A, et al. German Diabetes

Study (GDS) Group. Early detection of nerve fiber loss by corneal

confocal microscopy and skin biopsy in recently diagnosed type 2

diabetes. Diabetes. 2014 Jul;63(7):2454-63.

[22]Jiang MS, Yuan Y, Gu ZX, et al. Corneal confocal

microscopy for assessment of diabetic peripheral neuropathy: a

meta-analysis. Br J Ophthalmol. 2016 Jan;100(1):9-14.

[23]Cozzini T, Piona C, Marchini G, et al. In vivo confocal

microscopy study of corneal nerve alterations in children

and youths with Type 1 diabetes. Pediatr Diabetes. 2021

Aug;22(5):780-786.

[24]Malhotra D, Casey JR. Molecular Mechanisms of Fuchs

and Congenital Hereditary Endothelial Corneal Dystrophies. Rev

Physiol Biochem Pharmacol. 2020;178:41-81.

[25]Leelawongtawun W, Surakiatchanukul B, Kampitak K,

et al. Study of Corneal Endothelial Cells Related to Duration in

Diabetes. J Med Assoc Thai. 2016 Jul;99 Suppl 4:S182-8.

[26]Amador-Muñoz DP, Conforti V, Matheus LM, et

al. Diabetes Mellitus Type 1 has a Higher Impact on Corneal

Endothelial Cell Density and Pachymetry than Diabetes Mellitus

Type 2, Independent of Age: A Meta-Regression Model. Cornea.

2022 Aug 1;41(8):965-973.


(2 摘要 Views, 2 PDF Downloads)

Refbacks

  • 当前没有refback。