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星形胶质细胞在慢性疼痛中的分子机制研究进展

秦 乐, 于 子龙, 盛 端阳, 王 林*

摘要

由于神经系统复杂,慢性疼痛的机制研究具有挑战性。星形胶质细胞(astrocyte 或 astroglial cell,AC)是中枢神经
系统中最丰富的胶质细胞,在包括慢性疼痛等多种疾病病理条件下发挥重要作用。在慢性疼痛条件下,AC 通过神经元 -
胶质细胞和胶质 - 胶质细胞相互作用调节伤害感觉突触传递和网络功能,放大疼痛信号。AC 在慢性疼痛的情感和记忆相
关方面的重要作用也越来越清楚。因此,本文综述了我们目前对 AC 在慢性疼痛中的作用,以及它们的细胞和分子作用机制。

关键词

星形胶质细胞;慢性疼痛;分子机制

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