非免疫缺陷成人重症腺病毒肺炎致 ARDS 合并肝功能损害一例并文献复习
摘要
为少见。本文结合非免疫缺陷成年人重症腺病毒感染致 ARDS 并严重肝功能害的临床病例及文献复习,总结其临床特征,
以提高临床对该病的认识,提高临床救治率。该文报道 1 例 40 岁男性患者既往体健,以高热,咳嗽为首发表现,病情进展
迅速,一周内出现喘憋,I 型呼吸衰竭,重症肺炎,急性呼吸窘迫综合征(ARDS),同时合并严重肝功能损伤,行痰 NGS
检查发现人类哺乳动物腺病毒 B 组,明确为重症腺病毒感染,给予气管插管呼吸机辅助通气治疗,俯卧位通气以及积极抗
病毒,糖皮质激素,免疫调节等治疗后患者一周内成功脱机拔管好转出院。
关键词
全文:
PDF参考
[1]Lewis PF,Schmidt MA,Lu X,et al.A community-based
outbreak of severe respiratory illness caused by human adenovirus
serotype 14 [J],J Infect Dis,2009,199 ( 10) : 1427–1434.
[2]Garnett CT, Erdman D, Xu W, Gooding LR. Prevalence
and quantitation of species C adenovirus DNA in human
mucosallymphocytes. J Virol 2002;76(21):10608–10616
[3]Bil-Lula I, Ussowicz M, Rybka B, et al. Hematuria due
to adenoviral infection in bone marrow transplant recipients.
ransplant Proc 2010;42(9):3729–3734
[4]Walls T, Hawrami K, Ushiro-Lumb I, Shingadia D, Saha
V, Shankar AG. Adenovirus infection after pediatric bone marrow
transplantation: is treatment always necessary? Clin Infect Dis
2005;40(9): 1244–1249
[5]Filho EP, da Costa Faria NR, Fialho AM, et al.
Adenoviruses associated with acute gastroenteritis in hospitalized
and community children up to 5 years old in Rio de Janeiro and
Salvador, Brazil. J Med Microbiol 2007;56(Pt 3):313–319
[6]Mehta RS,SmithRE.Hemophagocytic lymphohistiocytosis (
HLH) : a review of literature[J].Med ncol,2013,30(4):740.
[7] 张晓辉 , 黄建安 , 陈澄 . 三例非免疫缺陷出现急性呼
吸窘迫综合征的重症腺病毒肺炎患者临床诊治 [J]. 中国呼吸
与危重监护杂志 , 2022, 21 (12): 861-866。
[8] 张谨 , 赵大海 . 非免疫缺陷成人重症腺病毒 B 组 55
型肺炎 1 例 [J]. 临床肺科杂志 , 2020, 25 (03): 480-482.
[9] 尹辉明 , 邱飞 , 谌绍林等 . 成人重症腺病毒肺炎的临
床特点与诊疗分析 [J]. 中国呼吸与危重监护杂志 , 2021, 20
(06): 424-426.
[10] 邵晓冬 , 林浩 , 郭晓钟 . 成人腺病毒感染致肝内胆
汁淤积为主要表现的多器官损害一例并文献复习 [J]. 中华临
床医师杂志 ( 电子版 ), 2013, 7 (06): 2727-2729.
[11]Cimsit B,Tichy EM,Patel SB,et al.Treatment of
adenovirus hepatitis with cidofovir in a pediatric liver transplant
recipient. Pediatr Transplant,2012,16: E90-93.
[12]Ison MG, Green M; AST Infectious Diseases Community
of Practice. Adenovirus in solid organ transplant recipients. Am J
Transplant 2009;9(4, Suppl 4):S161–S165
[13]Echavarría M. Adenoviruses in immunocompromised
hosts. Clin Microbiol Rev 2008;21(4):704–715
[14]Kuschner RA, Russell KL, Abuja M, et al; Adenovirus
Vaccine Efficacy Trial Consortium. A phase 3, randomized,
double-blind, placebo-controlled study of the safety and efficacy
of the live, oral adenovirus type 4 and type 7 vaccine, in U.S.
military recruits. Vaccine 2013;31(28):2963–2971
[15]Radin JM, Hawksworth AW, Blair PJ, et al. Dramatic
decline of respiratory illness among US military recruits
after the renewed use of adenovirus vaccines. Clin Infect Dis
2014;59(7):962–968
[16]Yusuf U, Hale GA, Carr J, et al. Cidofovir for the
treatment of adenoviral infection in pediatric hematopoietic stem
cell transplant patients. Transplantation 2006;81(10):1398–1404
[17]Keswani M, Moudgil A. Adenovirus-associated
hemorrhagic cytitis in a pediatric renal transplant recipient.
Pediatr Transplant 2007;11(5):568–571
[18]Doan ML, Mallory GB, Kaplan SL, et al. Treatment of
adenovirus pneumonia with cidofovir in pediatric lung transplant
recipients. J Heart Lung Transplant 2007;26(9):883–889
[19]Florescu MC, Miles CD, Florescu DF. What do we know
about adenovirus in renal transplantation? Nephrol Dial Transplant
2013;28(8):2003–2010
[20] 王煦 , 闫虹 . 更昔洛韦治疗小儿腺病毒感染性心
肌炎的临床疗效及对心肌酶的影响分析 [J]. 社区医学杂志 ,
2017, 15 (08): 74-75.
[21] 王雅波 , 陈诚 , 张蓉等 . 成人腺病毒感染重症肺炎 2
例 [J]. 中国乡村医药 , 2020, 27 (21): 44-45.
[22] 耿玉青 , 王雪峰 , 曹静 . 银翘白虎汤联合利巴韦林治
疗小儿急性上呼吸道腺病毒感染的疗效及对血清 TNF-α、
CRP 及 IL-6 的影响 [J]. 中国中医急症 , 2018, 27 (04): 601-
603+607
[23] 肖志刚 , 陈爱萍 , 肖宗浩 . 人免疫丙种球蛋白不同
给药方式治疗重症腺病毒肺炎的疗效分析 [J]. 中国实用医
药 , 2021, 16 (27): 142-145.
[24] 金骥翔 , 陈冰蓉 . 免疫球蛋白联合抗病毒药物治疗
腺病毒肺炎患儿的临床疗效和对 T 淋巴细胞亚群的影响 [J].
中国妇幼保健 , 2021, 36 (14): 3246-3249.
[25] 陈颖萍 , 马冬梅 , 刘国华等 . 更昔洛韦联合人免疫
球蛋白治疗小儿腺病毒肺炎的临床研究 [J]. 中国医药指南 ,
2018, 16 (23): 83.
(6 摘要 Views, 2 PDF Downloads)
Refbacks
- 当前没有refback。