血压与糖尿病视网膜病变的关联：双样本孟德尔随机化研究
摘要
纯性 DR 的因果关系。方法 进行单变量和多变量孟德尔随机化分析。逆方差加权是用于分析因果关系的主要方法，并伴有
几种敏感性 MR 分析。结果 遗传预测的原发性高血压、更高的收缩压与 DR 风险增加相关。原发性高血压，MR 分析仅支
持原发性高血压和单纯性 DR 高风险有关。结论 研究表明，原发性高血压、过高的收缩压和舒张压可能会增加 DR 的风险。
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[1]BRYL A, MRUGACZ M, FALKOWSKI M, et al.
The Effect of Diet and Lifestyle on the Course of Diabetic
Retinopathy-A Review of the Literature[J]. NUTRIENTS,
2022,14(6).
[2]FONG D S, AIELLO L P, FERRIS F L, et al. Diabetic
retinopathy[J]. DIABETES CARE, 2004,27(10): 2540-2553.
[3]JAMPOL L M, GLASSMAN A R, SUN J. Evaluation and
Care of Patients with Diabetic Retinopathy[J]. NEW ENGLAND
JOURNAL OF MEDICINE, 2020,382(17): 1629-1637.
[4]PINTO C C, SILVA K C, BISWAS S K, et al. Arterial
hypertension exacerbates oxidative stress in early diabetic
retinopathy[J]. FREE RADICAL RESEARCH, 2007,41(10):
1151-1158.
[5]EMDIN C A, RAHIMI K, NEAL B, et al. Blood Pressure
Lowering in Type 2 Diabetes A Systematic Review and Metaanalysis[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL
ASSOCIATION, 2015,313(6): 603-615.
[6]ANONYMOUS. Tight blood pressure control and risk of
macrovascular and microvascular complications in type 2 diabetes:
UKPDS 38. UK Prospective Diabetes Study Group.[J]. BMJ
(Clinical research ed.), 1998,317(7160): 703-713.
[7]SAEEDI P, PETERSOHN I, SALPEA P, et al. Global and
regional diabetes prevalence estimates for 2019 and projections
for 2030 and 2045: Results from the International Diabetes
Federation Diabetes Atlas, 9th edition[J]. DIABETES RESEARCH
AND CLINICAL PRACTICE, 2019,157.
[8] 鲜圆圆 , 高静 , 柏丁兮 , 等 . 中国老年人糖尿病前期
患病率的 Meta 分析 [J]. 军事护理 ,2022,39(12):62-65,100.
[9] 北京高血压防治协会 , 中国老年学和老年医学学会 ,
北京市社区卫生协会 , 等 . 成人高血压合并 2 型糖尿病和血
脂异常基层防治中国专家共识 (2024 年版 )[J]. 中国全科医
学 ,2024,27(28):3453-3475,3482.
[10]KLAG M J, WHELTON P K, RANDALL B L, et al.
Blood pressure and end-stage renal disease in men.[J]. The New
England journal of medicine, 1996,334(1): 13-18.
[11] 田蓉 , 傅桂芬 , 李丽蓉 , 等 . 老年 T2DM 合并高血
压患者发生糖尿病肾病的影响因素 [J]. 心血管康复医学杂
志 ,2023,32(1):4-8.
[12]CHATURVEDI N, PORTA M, KLEIN R, et al. Effect of
candesartan on prevention (DIRECT-Prevent 1) and progression
(DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised,
placebo-controlled trials[J]. LANCET, 2008,372(9647): 1394-
1402.
[13]LAWLOR D A, HARBORD R M, STERNE J A C, et al.
Mendelian randomization: Using genes as instruments for making
causal inferences in epidemiology[J]. STATISTICS IN MEDICINE,
2008,27(8): 1133-1163.
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