开放期刊系统

真菌性角膜炎的临床研究进展

潘 纪阳, 陈 颖欣

摘要

真菌性角膜炎是我国角膜盲的重要原因。与其他感染性角膜炎相比,其预后明显更差。真菌性角膜炎在诊断和治
疗方面存在诸多问题,包括实验室诊断困 难、抗真菌药物的穿透性和生物利用度不足等。近年来,随着实验室检测技术、
影像学诊断技术和治疗方法在不断更新进步,真菌性角膜炎的愈后也在不断提高。 因此,总结近年来相关研究成果,就真菌
性角膜炎的实验室及影像学诊断、药物 及手术治疗等方面的新进展进行综述,为真菌性角膜炎的诊断和治疗提供参考依据。

关键词

真菌;角膜溃疡;角膜炎;药物;手术

全文:

PDF

参考

[1]PEI Y, CHEN X, TAN Y, 等 . Microbiological Profiles

of Ocular Fungal Infection at an Ophthalmic Referral Hospital in

Southern China: A Ten-Year Retrospective Study[J/OL].Infection

and Drug Resistance,2022(15):3267-3276.

[2]HOFFMAN J J, YADAV R, SANYAM S D, 等 .Microbial

Keratitis in Nepal: Predicting the Microbial Aetiology from

Clinical Features[J/OL].Journal ofFungi,2022,8(2): 201.

[3] 蓝倩倩 , 陈琦 , 陈丽妃 , 等 . 共聚焦显微镜在真菌性

角膜炎诊治中的临床应用 [J]. 国际眼科杂志 ,2019,19(3):523-

526.

[4]SAINI J S,JAINA K, KUMAR S, 等 .Neural network

approach to classify infective keratitis[J/OL].Current Eye

Research,2003, 27(2):111-116.

[5]PRAJNA N V, KRISHNAN T, MASCARENHAS J,

等 . The Mycotic Ulcer Treatment Trial[J]. JAMA ophthalmolo

gy,2013,131(4):422-429.

[6]SPIERER O, DUGAR J, MILLER D, 等 .Comparative

antifungal susceptibility analysis of Candida albicans

versus non-albicans Candida corneal isolates[J/OL].

Cornea,2015,34(5):576-579.

[7]PRAJNA N V, KRISHNAN T, RAJARAMAN R, 等 .

Effect of Oral Voriconazole on Fungal Keratitis in the Mycotic

Ulcer Treatment Trial II(MUTT II):A Randomized Clinical

Trial[J/OL]. JAMA ophthalmology,2016,134(12):1365-1372.

[8]PRAJNA N V,KRISHNAN T RAJARAMAN R, 等 .

Adjunctive Oral Voriconazole Treatment of Fusarium Keratitis:A

Secondary Analysis From the Mycotic Ulcer Treatment Trial

II[J/OL].JAMA ophthalmology,2017,135(6):520-525.

[9] 白利广 , 王峰 . 角膜基质内注射不同浓度伏立康唑治

疗真菌性角膜炎 [J/OL]. 眼科新进展 ,2020,40(5): 466-469.

[10]NARAYANA S, KRISHNAN T, RAMAKRISHNAN S,

等 . Mycotic Antimicrobial Localized Injection: A Randomized

Clinical Trial Evaluating Intrastromal Injection of

Voriconazole[J/OL]. Ophthalmology,2019,126(8):1084-1089.

[11]SHARMA B, KATARIA P, ANAND R, 等 . Efficacy

Profile of Intracameral Amphotericin B. The Often Forgotten

Step[J/OL]. Asia-Pacific Journal of Ophthalmology (Philadelphia,

Pa.),2015,4(6):360-366.

[12]WAN L, CHENG J, ZHANG J, 等 . RISK FACTORS,

T R E A T M E N T S T R A T E G I E S , A N D O U T C O M E S O F

ENDOPHTHALMITIS ASSOCIATED WITH SEVERE FUNGAL

KERATITIS[J/OL]. Retina,2019,39(6):1076-1082.

[13] 潘士印 , 安娜 , 肖湘华 , 等 . 角膜胶原交联方法联合

那他霉素抗真菌效果研究 [J]. 国际眼科杂志 ,2019,19(1):14-

20.

[14]MUNDRA J, DHAKAL R, MOHAMED A, 等 .

Outcomes of therapeutic penetrating keratoplasty in 198 eyes

with fungal keratitis[J/OL].Indian Journal of Ophthalmology,

2019, 67(10): 1599-1605.

[15]UCHIO E, SAEKI Y, TSUKAHARA-KAWAMURA

T, 等 .Clinical outcome after air-assisted manual deep anterior

lamellar keratoplasty for fungal keratitis poorly responsive to

medical treatment[J/OL].Clinical Ophthalmology (Auckland,

N.Z.),2019(13):1913-1919.


(6 摘要 Views, 32 PDF Downloads)

Refbacks

  • 当前没有refback。