高级别胶质瘤患者生命末期护理的临床研究
摘要
床研究，以期为临床诊治提供参考。 方法：回顾性分析本院于 2020 年 1 月 -2023 年 1 月期间接受 HGG 转为姑息治疗 (PC)
患者 52 例，另选择未转诊至 PC 的 HGG 患者 (n=80) 和转诊为 PC 的非中枢神经系 统肿瘤患者 (n=80) 进行对比。根据预
先确定的变量计算每个患者在 EOL 医疗护理 积极程度的综合得分。当符合基于症状负担、功能状态和预后的预定标准时，
为 每个患者定义适合接受 PC 的时间。结果：在 HGG 转诊至 PC 的患者中，59.6%(N=31) 转诊为住院患者，53.8%(N=28)
转诊在生命最后 12 周内。无论 PC 转诊与否，HGG 患者在 EOL 有相似的积极护理，而 HGG 患者在 EOL 有比非中枢神
经系统癌症患者 更少的积极护理 (p=0.007)。在接受晚期 PC 转诊的 HGG 患者中，EOL 护理比早期 PC 转诊的患者更积
极 (p=0.012)。符合条件时运动无力 (OR=2.55，p=0.002) 和更 多的疾病进展 (OR=1.25，p=0.043) 与 EOL 较不积极的护理
相关。结论：早期临床 和疾病相关特征预测 HGG 患者在 EoL 进行积极的医疗护理，PC 在改善 HGG 患者 EoL 结局方面
的作用值得进一步评估。
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