关于心脏骤停猪模型复苏后 Alda-1 使用抑制铁死亡对脑损伤的研究
摘要
其脑氧微循环系统中铁死亡（Ferroptosis）的发生机制及其对脑组织损伤的影响。研究通过构建稳定的 CA-CPR 猪模型，
结合生化检测、组织病理学分析及先进的分子生物学技术，详细评估了乙醛脱氢酶 2（Aldehyde Dehydrogenase 2, ALDH2）
特异性激活剂 Alda-1 在减轻复苏后脑损伤中对铁死亡过程的调控作用。结果显示，Alda-1 的干预显著减轻了心脏骤停后
猪模型复苏过程中的脑组织损伤程度，这一保护作用可能与抑制长链脂酰辅酶 A 合成酶 4（ACSL4）以及上调谷胱甘肽过
氧化物酶 4（GPx4）的表达，进而阻断由铁死亡信号通路所介导的脑细胞程序性死亡过程有关。
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