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低氧诱导因子 - 脯氨酰羟化酶抑制剂治疗合并心力衰竭非透析慢性肾性贫血 1 例报告

王 晓彤, 易 娜

摘要

肾性贫血 (Renal anemia, RA) 是慢性肾脏病 (Chronic kidney disease, CKD) 的常见并发症,目前促红细胞生成素
(Erythropoietin,EPO)及铁剂主要用于治疗肾性贫血提升血红蛋白水平,然而,在炎症状态、铁缺乏情况下无法有效纠正贫血,
且大量应用促红细胞生成素及静脉应用铁剂所带来的心血管事件等并发症不容忽视。低氧诱导因子 - 脯氨酰羟化酶抑制剂
(Hypoxia inducible factor-prolyl hydroxylase,HIF-PH)罗沙司他具有纠正贫血及调节铁代谢的特点,已成为肾性贫血治疗
的一种新手段。本文报道一例罗沙司他在非透析慢性贫血的应用,以加强对该药物的认识。

关键词

肾性贫血;促红细胞生成素;低氧诱导因子 - 脯氨酰羟化酶抑制剂;罗沙司他

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参考

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