低氧诱导因子 - 脯氨酰羟化酶抑制剂治疗合并心力衰竭非透析慢性肾性贫血 1 例报告
摘要
(Erythropoietin,EPO)及铁剂主要用于治疗肾性贫血提升血红蛋白水平,然而,在炎症状态、铁缺乏情况下无法有效纠正贫血,
且大量应用促红细胞生成素及静脉应用铁剂所带来的心血管事件等并发症不容忽视。低氧诱导因子 - 脯氨酰羟化酶抑制剂
(Hypoxia inducible factor-prolyl hydroxylase,HIF-PH)罗沙司他具有纠正贫血及调节铁代谢的特点,已成为肾性贫血治疗
的一种新手段。本文报道一例罗沙司他在非透析慢性贫血的应用,以加强对该药物的认识。
关键词
全文:
PDF参考
[1]Yogasundaram Haran,Chappell Mark C ,Braam Branko
et al. Cardiorenal Syndrome and Heart Failure-Challenges and
Opportunities. [J] .Can J Cardiol, 2019; 35: 1208-1219.
[2] 中 国 研 究 型 医 院 学 会 肾 脏 病 学 专 业 委 员 会 . 罗
沙司他治疗肾性贫血中国专家共识 [J]. 中华医学杂志,
2022,102(24):1802-1810.
[3]Rao M, et al. Kidney Int 2005; 68(4):1432-1438
[4] 汪杨 , 魏日胞 . 慢性肾脏病肾性贫血的基础与临床研
究现状及进展 [J]. 中国中西医结合肾病杂志 ,2019,20(05):452-
455.
[5]Lucia Del Vecchio, Roberto Minutolo. ESA, Iron Therapy
and New Drugs: Are There New Perspectives in the Treatment
of Anaemia?[J].J.Clin.Med.2021;10,839.
Solomon SD, et al. N Engl J Med. 2010;Sep 16;363(12):1146-
55.
[6]Nupur Gupta, MD, Jay B. Wish,et,al. Hypoxia-Inducible
Factor Prolyl Hydroxylase Inhibitors:A Potential New Treatment
for Anemia in Patients With CKD [J]. Am J Kidney Dis.
2017;69(6):815-826
[7]Zhang L, Hou J, Li J,et,al. Roxadustat for the treatment
of anemia in
patients with chronic kidney diseases: a meta-analysis.
Aging (Albany NY)[J]. 2021;13(13):17914-17929.
[8]Bo Liu, Tiantian Shi, Shaojiang Tian,et,al. Efficacy
and Mechanism of Roxadustat plus Oral Iron in the[J]. Evid Based
Complement Alternat Med. 2022;2022:9192655.
[9]Robert Provenzano, Lynda Szczech, Robert Leong, et, al.
Efficacy and Cardiovascular Safety of Roxadustat for Treatment of
Anemia in Patients with Non-Dialysis-Dependent CKD: Pooled
Results of Three Randomized Clinical Trials [J].Clin J Am Soc
Nephrol. 2021;16(8):1190-1200.
[10] 谷茜,景三辉,吴歌 . 罗沙司他口服治疗肾性贫血
效果观察 [J]. 山东医药 .2022, 62(12):60-63.
[11] 中国医师协会肾脏内科医师分会肾性贫血指南
工作组 . 中国肾性贫血诊治临床实践指南 [J]. 中华医学杂
志 .2021,101(20):1463-1502.
[12]Palazzuoli, Alberto MD, PhD , et, al.β-Erythropoietin
Effects on Ventricular Remodeling, Left and Right Systolic
Function, Pulmonary Pressure, and Hospitalizations in
Patients Affected With Heart Failure and Anemia[J].Journal of
Cardiovascular Pharmacology.2009; 53(6):462-467.
[13]Wolf G, Müller N, Hunger-Battefeld W, et, al.
Hemoglobin concentrations are closely linked to renal function in
patients with type 1 or 2 diabetes mellitus[J]. Kidney Blood Press
Res. 2008;31(5):313-21.
(7 摘要 Views, 9 PDF Downloads)
Refbacks
- 当前没有refback。