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多发性骨髓瘤的非典型临床表现综述

张 宝仁

摘要

多发性骨髓瘤 (multiple myeloma,MM) 1 是一种恶性浆细胞克隆性疾病。其发病率在我国近年
呈逐渐上升趋势,是血液系统中第 2 位的常见恶性肿瘤之一 2,3。目前,临床上对于 MM 的致病原因及具体发
病机制尚未完全阐述清楚,但分析以往临床病例资料可知其为骨髓内恶性浆细胞增殖或伴有侵润髓外,并分泌
大量单克隆免疫球蛋白对人体各器官组织造成一定的损害 4,因此其临床表现复杂多样。

关键词

多发性骨髓瘤;诊断;非典型临床表现

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参考

[1]Medical Masterclass c, Firth J. Haematology:

multiple myeloma. Clin Med (Lond) 2019; 19(1): 58-60.

[2]Liu W, Liu J, Song Y, et al. Mortality of

lymphoma and myeloma in China, 2004-2017: an

observational study. J Hematol Oncol 2019; 12(1): 22.

[3]Wang S, Xu L, Feng J, et al. Prevalence and Incidence

of Multiple Myeloma in Urban Area in China: A National

Population-Based Analysis. Front Oncol 2019; 9: 1513.

[4]Riccomi G, Fornaciari G, Giuffra V. Multiple

myeloma in paleopathology: A critical review. Int J

Paleopathol 2019; 24: 201-12.

[5]Eslick R, Talaulikar D. Multiple myeloma: from

diagnosis to treatment. Aust Fam Physician 2013; 42(10):

684-8.

[6]Rajkumar SV, Kyle RA. Multiple myeloma:

diagnosis and treatment. Mayo Clin Proc 2005; 80(10):

1371-82.

[7]Kyle RA, Gertz MA, Witzig TE, et al. Review

of 1027 patients with newly diagnosed multiple myeloma.

Mayo Clin Proc 2003; 78(1): 21-33.

[8]Eleutherakis-Papaiakovou V, Bamias A, Gika

D, et al. Renal failure in multiple myeloma: incidence,

correlations, and prognostic significance. Leuk Lymphoma

2007; 48(2): 337-41.

[9]Palumbo A, Anderson K. Multiple myeloma. N

Engl J Med 2011; 364(11): 1046-60.

[10]Varettoni M, Corso A, Pica G, Mangiacavalli S,

Pascutto C, Lazzarino M. Incidence, presenting features and

outcome of extramedullary disease in multiple myeloma:

a longitudinal study on 1003 consecutive patients. Ann

Oncol 2010; 21(2): 325-30.

[11]Palumbo A, Bringhen S, Ludwig H, et al.

Personalized therapy in multiple myeloma according to patient

age and vulnerability: a report of the European Myeloma

Network (EMN). Blood 2011; 118(17): 4519-29.

[12]Plummer C, Driessen C, Szabo Z, Mateos MV.

Management of cardiovascular risk in patients with multiple

myeloma. Blood Cancer J 2019; 9(3): 26.

[13]Shah KB, Inoue Y, Mehra MR. Amyloidosis and

the heart: a comprehensive review. Arch Intern Med 2006;

166(17): 1805-13.

[14]Oberti L, Rognoni P, Barbiroli A, et al.

Concurrent structural and biophysical traits link with

immunoglobulin light chains amyloid propensity. Sci Rep

2017; 7(1): 16809.

[15]Falk RH, Alexander KM, Liao R, Dorbala S.

AL (Light-Chain) Cardiac Amyloidosis: A Review of

Diagnosis and Therapy. J Am Coll Cardiol 2016; 68(12):

1323-41.

[16]Thomas FB, Clausen KP, Greenberger NJ. Liver

disease in multiple myeloma. Arch Intern Med 1973;

132(2): 195-202.

[17]Pozzi C, Locatelli F. Kidney and liver

involvement in monoclonal light chain disorders. Semin

Nephrol 2002; 22(4): 319-30.

[18]Perez-Soler R, Esteban R, Allende E, Tornos

Salomo C, Julia A, Guardia J. Liver involvement in

multiple myeloma. Am J Hematol 1985; 20(1): 25-9.

[19]Chang SS, Lu CL, Tsay SH, Chang FY, Lee SD.

Amyloidosis-induced gastrointestinal bleeding in a patient with

multiple myeloma. J Clin Gastroenterol 2001; 32(2): 161-3.

[20]Lopes da Silva R. Extramedullary plasmacytoma

of the small intestine: clinical features, diagnosis and

treatment. J Dig Dis 2012; 13(1): 10-8.

[21]Lin M, Zhu J, Shen H, Huang J. Gastrointestinal

bleeding as an initial manifestation in asymptomatic

multiple myeloma: A case report and review of the

literature. Oncol Lett 2013; 5(1): 218-20.

[22]Daram SR, Paine ER, Swingley AF. Upper

gastrointestinal bleeding in a patient with multiple

myeloma. Gastroenterology 2012; 142(2): e8-9.

[23]DiMinno G, Coraggio F, Cerbone AM, et

al. A myeloma paraprotein with specificity for platelet

glycoprotein IIIa in a patient with a fatal bleeding disorder.

J Clin Invest 1986; 77(1): 157-64.

[24]Saif MW, Allegra CJ, Greenberg B. Bleeding

diathesis in multiple myeloma. J Hematother Stem Cell

Res 2001; 10(5): 657-60.

[25]Chakraborty SK, Chowdhury A, Kar S, Mondal

S, Basu S, Ahmed AA. Multiple myeloma presenting

as malabsorption syndrome due to amyloidosis. J Assoc

Physicians India 2000; 48(9): 931-2.

[26]Narvaez J, Hernandez MV, Ruiz JM, Vaquero

CG, Juanola X, Nollaa JM. Rituximab therapy for AAamyloidosis secondary to rheumatoid arthritis. Joint Bone

Spine 2011; 78(1): 101-3.

[27]Goranov S. Clinical problems of infectious

complications in patients with multiple myeloma. Folia

Med (Plovdiv) 1994; 36(1): 41-6.

[28]Hughes JC, Votaw ML. Pleural effusion in

multiple myeloma. Cancer 1979; 44(3): 1150-4.

[29]Kintzer JS, Jr., Rosenow EC, 3rd, Kyle RA.

Thoracic and pulmonary abnormalities in multiple

myeloma. A review of 958 cases. Arch Intern Med 1978;

138(5): 727-30.

[30]Kamble R, Wilson CS, Fassas A, et al. Malignant

pleural effusion of multiple myeloma: prognostic factors

and outcome. Leuk Lymphoma 2005; 46(8): 1137-42.

[31]Billecke L, Murga Penas EM, May AM, et al.

Cytogenetics of extramedullary manifestations in multiple

myeloma. Br J Haematol 2013; 161(1): 87-94.

[32]Rosinol L, Cibeira MT, Blade J, et al.

Extramedullary multiple myeloma escapes the effect of

thalidomide. Haematologica 2004; 89(7): 832-6.


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