CISD2 的生物学作用及其在肿瘤发生的研究进展
摘要
和线粒体相关膜 (MAM)，在调节胞质 Ca2+ 稳态，铁离子代谢，维持内质网完整性和线粒体功能中起着关键作
用。最近报道 CISD2 的异常表达与各种癌细胞的增殖、分化、转移和侵袭密切相关，但其调节肿瘤发生的分子
机制尚不清楚。因此，CISD2 的表达和生物学功能可能是治疗肿瘤相关疾病的潜在靶点。本文从 Pubmed 上收
集近年来 CISD2 在各种肿瘤疾病中的作用机制，为相关研究提供理论参考。
关键词
全文:
PDF参考
[1] Jelic, M., et al., Oxidative stress and its role in
cancer. Journal of cancer research and therapeutics, 2021.
17(1): p. 22-28.
[2] Chen, Y., et al., Upregulation of Cisd2 attenuates
Alzheimer's-related neuronal loss in mice. The Journal of
pathology, 2020. 250(3): p. 299-311.
[3] Wang, L., et al., Overexpressed CISD2 has
prognostic value in human gastric cancer and promotes
gastric cancer cell proliferation and tumorigenesis via AKT
signaling pathway. Oncotarget, 2016. 7(4): p. 3791-805.
[4] Chen, B., et al., CISD2 associated with
proliferation indicates negative prognosis in patients with
hepatocellular carcinoma. International journal of clinical
and experimental pathology, 2015. 8(10): p. 13725-38.
[5] Darash-Yahana, M., et al., Breast cancer
tumorigenicity is dependent on high expression levels of
NAF-1 and the lability of its Fe-S clusters. Proceedings of
the National Academy of Sciences of the United States of
America, 2016. 113(39): p. 10890-5.
[6] Holt, S., et al., Activation of apoptosis in NAF-
1-deficient human epithelial breast cancer cells. Journal of
cell science, 2016. 129(1): p. 155-65.
[7] Liu, L., et al., CISD2 expression is a novel marker
correlating with pelvic lymph node metastasis and prognosis
in patients with early-stage cervical cancer. Medical
oncology (Northwood, London, England), 2014. 31(9): p.
183.
[8] Li, S., et al., Upregulation of CISD2 augments
ROS homeostasis and contributes to tumorigenesis and
poor prognosis of lung adenocarcinoma. Scientific reports,
2017. 7(1): p. 11893.
[9] Yang, Y., Y. Bai, and Q. Wang, CDGSH Iron
Sulfur Domain 2 Activates Proliferation and EMT of
Pancreatic Cancer Cells via Wnt/β-Catenin Pathway
and Has Prognostic Value in Human Pancreatic Cancer.
Oncology research, 2017. 25(4): p. 605-615.
[10] Liao, H., B. Liao, and H. Zhang, CISD2 plays
a role in age-related diseases and cancer. Biomedicine &
pharmacotherapy = Biomedecine & pharmacotherapie,
2021. 138: p. 111472.
[11] Yang, L., et al., A novel prognostic score model
incorporating CDGSH iron sulfur domain2 (CISD2)
predicts risk of disease progression in laryngeal squamous
cell carcinoma. Oncotarget, 2016. 7(16): p. 22720-32.
(32 摘要 Views, 66 PDF Downloads)
Refbacks
- 当前没有refback。