基于骨细胞调节机制谈铁代谢与骨质疏松
摘要
调节机制有助于骨质疏松的治疗和预防。文章通过总结近年来有关铁代谢对骨稳态的影响，讨论了铁代谢在骨
质疏松中的作用，提出铁相关制剂治疗骨质疏松的前景，指出骨质疏松临床研究的潜在方向。
关键词
全文:
PDF参考
[1] 黎淼 , 何琪 , 曾嘉旭 , 等 . 骨科相关疾病发生
发展中的铁超载 [J]. 中国组织工程研究，2023,27(17):2
723-2728.
[2] LI J, CAO F , YIN HL, et al. Ferroptosis: past,
present and future[J].Cell Death Dis.2020;11(2):88.
[3] Billesbolle C B,A. Dasgupta, P. S. Rosenberg, et
al. Structure of hepcidin-bound ferroportin reveals iron
homeostatic mechanisms[J]. Nature 586,807–811(2020).
[4] Pasricha S R,Tye-Din J, Muckenthaler M U,et
al. Iron deficiency[J].Lancet 397, 233–248 (2021).
[5] 张伟，李光飞，徐又佳，等 . 铁稳态与骨质疏
松 [J]. 中国骨质疏松杂志，2013,19(12):1291-1295.
[6] Hirota K,Collins F,Rios-Arce N,An intimate
crosstalk between iron homeostasis and oxygen meta_xfffe_bolism regulated by the hypoxia-inducible factors (HIFs)[J].
Free Radic. Biol. Med.133, 118–129 (2019).
[7] 魏戌，刘宁，章轶立，等 . 骨质疏松症的共病
研究与早期筛查 [J]. 中国全科医学，2022,25(35):4369-
4374.
[8] 万超超，曹林忠，王多贤，等 . 成骨细胞铁
代谢异常的研究进展 [J]. 中国骨质疏松杂志，2023，
29(5):691-695（700）.
[9] Robach P,Whittow C, Aartun J,et al. Alterations
of systemic and muscle iron metabolism in human subjects
treated with low-dose recombinant erythropoietin[J].
Blood 113,6707–6715(2009).
[10] Kautz L.Engdahl C, Henning P,et al.
Identification of erythroferrone as an erythroid regulator of
iron metabolism[J].Nat. Genet.46,678–684(2014).
[11] Coffey R,Coudert AE，Callebert J，et al.
Erythroid overproduction of erythroferrone causes iron
overload and developmental abnormalities in mice[J].Blood
139,439–451(2022).
[12] Mayeur C,Coudert E，Callebert J，et al. The
type I BMP receptor Alk3 is required for the induction of
hepatic hepcidin gene expression by interleukin-6[J].Blood
123,2261–2268(2014).
[13] Hentze MW,Muckenthale MU, Galy B , et al.
Two to tango:regulation of Mammalian iron metabolism[J].
Cell 142,24–38 (2010).
[14] den Elzen WP,Camaschella C, et al. Plasma
hepcidin levels and anemia in old age. The Leiden 85-Plus
Study[J]. Haematologica 98, 448–454 (2013).
[15] Cui J,Liu Q,Sin L,et al. Osteocytes in bone
aging: advances, challenges, and future per-spectives[J].
Ageing Res.Rev.77,101608 (2022).
[16] Nakashima, T.Coutte F, Frémont M,et alet
al. Evidence for osteocyte regulation of bone homeostasis
through RANKL expression[J].Nat.Med.17,1231–1234
(2011).
[17] Zhang, F. Zhu Q,Xin K,et al. Metalloreductase
Steap3 coordinates the regulation of iron homeostasis
and inflammatory responses[J].Haematologica 97,1826–
1835(2012).
[18] Dong D.Lu W,Tian S,et al.16 T high static
magnetic field inhibits receptor activator of nuclear factor
kappa-Beta ligand-induced osteoclast differentiation by
regulat-ing iron metabolism in Raw264.7 cells[J].Tissue
Eng.Regen.Med 13,2181–2190(2019).
[19] Xu Z,Zhu L,Jing H,et al.The regulation of iron
metabolism by hepcidin contributes to unloading-induced
bone loss[J].Bone 94,152–161(2017).
[20] TSAY J, YANG Z, ROSS FP , et al. Bone loss
caused by iron overload in a murine model: importance of
oxidave stress[J]. Blood. 2010;116(14):2582-2589.
[21] LI G F , PAN YZ, SIROIS P , et al. Iron
homeostasis in osteoporosis and its clinical implicaons.
Osteoporos Int[J].2012;23(10):2403-2408.
[22] CHEN B, YAN YL, LIU C, et al. Therapeuc
effect of deferoxamine on iron overload-induced inhibion
of osteogenesis in a zebrafish model[J]. Calcif Tissue
Int.2014;94(3):353-360.
[23] JOMOVA K, VALKO M. Advances in metalinduced oxidave stress and human disease[J].Toxicology.
2011;283(2-3):65-87.
[24] JENEY V.Clinical Impact and Cellular
Mechanisms of Iron Overload-Associated Bone Loss[J].
Front Pharmacol.2017;8:77.
[25] Harris MM，Houtkooper LB，Stanford VA，
et al．Dietary iron is associated with bone mineral density
in healthy postmenopausal women[J].Nutr，2003，
133(11):3598-3602．
[26] Maurer J，Harris MM，Stanford VA，et al
．Dietary iron positively influences bone mineral density
in postmenopausal women on hormone replacement
therapy[J].Nutr，2005，135(4):863-869．
[27] Messer JG，Cooney PT，Kipp DE，et al.Iron
chelator deferoxamine alters iron-regulatory genes and
proteins and suppresses osteoblast phenotype in fetal rat
calvaria cells[J]. Bone，2010，46 (5):1408-1415．
[28] Zhou Y,Liu Q,Yang W, et al.Irp2 knockout
causes osteoporosis by inhibition of bone remo-deling[J].
Calcif.Tissue Int.104,70–78 (2019).
(17 摘要 Views, 131 PDF Downloads)
Refbacks
- 当前没有refback。