开放期刊系统

胰岛素抵抗对非酒精性脂肪肝发生的机理探讨

王 诗淇, 孙 鹏, 王 秀艳, 罗 念容

摘要

非酒精性脂肪肝病(nonalcoholicfattyliverdisease,NAFLD),作为一个全球性的流行病,已成为发达国家和富裕地区慢性肝病中的第一大病种。作为一种代谢综合症,NAFLD可在短期内发展为不可逆的肝损害,影响肝病患者生活质量和预期寿命。胰岛素抵抗对NAFLD发生发展有一定的作用。然而,目前对胰岛素影响NAFLD的机制了解仍不深入,本文拟对其进行探讨。

关键词

胰岛素抵抗;非酒精性脂肪肝

全文:

PDF

参考

developmentofnonalcoholicsteatohepatitis:pathophysiologyandclinicalimplications[J].Gastroenterology,2012(4):711-725.

[2]DanaeiG,FinucaneMM,LinJK,etal.National,regional,andglobaltrendsinsystolicbloodpressuresince1980:systematicanalysisofhealthexaminationsurveysandepidemiologicalstudieswith786country-yearsand5·4millionparticipants[J].Lancet,2011,377(9765):568-577.

[3]WilliamsR.Globalchallengesinliverdisease[J].Hepatology,2006,44(3):521-526.

[4]ChalasaniN,YounossiZ,LavineJE,etal.Thediagnosisandmanagementofnon-alcoholicfattyliverdisease:practiceGuidelinebytheAmericanAssociationfortheStudyofLiverDiseases,AmericanCollegeofGastroenterologyandtheAmericanGastroenterologicalAssociation[J].Hepatology,2012,55(6):2005-2023.

[5]AnguloP.Nonalcoholicfattyliverdisease[J].NEnglJMed,2002,346(16):1221-1231.

[6]PerryRJ,KimT,ZhangXM,etal.Reversalofhypertriglyceridemia,fattyliverdisease,andinsulinresistancebyaliver-targetedmitochondrialuncoupler[J].CellMetab,2013,18(5):740-748.

[7]AmericanLiverFoundation-EducationResources[Internet[J].cited,2015(11):89.

[8]ChinaHealthandNutritionSurvey—ChinaHealthandNutritionSurvey(CHNS)[Internet][J].[cited,2015(11):101.

[9]LiuS,YehTH,SinghVP,etal.β-cateninisessentialforethanolmetabolismandprotectionagainstalcohol-mediatedliversteatosisinmice[J].Hepatology,2012,55(3):931-940.

[10]曹颖,谢雯.非酒精性脂肪性肝病发病机制研究进展与现状[J].世界华人消化杂志,2017,25(8):670-683.

[11]WuH,NgR,ChenX,SteerCJ,SongG.MicroRNA-21isapotentiallinkbetweennon-alcoholicfattyliverdiseaseandhepatocellularcarcinomaviamodulationoftheHBP1-p53-Srebp1cpathway[J].Gut,2016,65(11):1850-1860.

[12]JanevskiM,RatnayakeS,SiljanovskiS,McGlynnMA,Cameron-SmithD,LewandowskiP.FructosecontainingsugarsmodulatemRNAoflipogenicgenesACCandFASandproteinlevelsoftranscriptionfactorsChREBPandSREBP1cwithnoeffectonbodyweightorliverfat[J].FoodFunct,2012,3(2):141-149.

[13]BenhamedF,DenechaudPD,LemoineM,etal.ThelipogenictranscriptionfactorChREBPdissociateshepaticsteatosisfrominsulinresistanceinmiceandhumans[J].JClinInvest,2012,122(6):2176-2194.

[14]尹定子,宋海云.Wnt信号通路:调控机理和生物学意义[J].中国细胞生物学学报,2011,33(02):103-111.

[15]SaravaniR,GalaviHR,NoorzehiN,RanjbarN,Mollashahee-KohkanF.CommonVariationsinPerilipinrs1052700andFTOrs3751812GeneVariants,andRiskforObesityandType-2Diabetes[J].RepBiochemMolBiol,2017,6(1):80-87.

[16]MongaSP.β-CateninSignalingandRolesinLiverHomeostasisInjuryandTumorigenesis[J].Gastroenterology,2015(7):1294-1310.

[17]DonnellyKL,SmithCI,SchwarzenbergSJ,JessurunJ,BoldtMD,ParksEJ.Sourcesoffattyacidsstoredinliverandsecretedvialipoproteinsinpatientswithnonalcoholicfattyliverdisease[J].JClinInvest,2005,115(5):1343-1351.

[18]LiuH,FergussonMM,WuJJ,etal.Wntsignalingregulateshepaticmetabolism[J].SciSignal,2011,4(158):58.

[19]LiuF,SongY,LiuD.Hydrodynamics-basedtransfectioninanimalsbysystemicadministrationofplasmidDNA[J].GeneTher,1999,6(7):1258-1266.

[20]颜少华,朱常琰,沈俊杰,高德化,张洪旭,韩思奕,游咏.VitD调控Wnt信号通路影响糖尿病心血管并发症的研究进展[J].生命的化学,2019,4(7):10.

[21]陈峰,何生松,吴梅梅,等.不同转染方式对GFP表达质粒在小鼠肝脏的表达影响-中国学术期刊网络出版总库[J].山东大学学报(医学版),2010(01):17-20.

[22]徐丽萍,马宁芳.Wnt/β-catenin信号通路与肝脏的发育及异常分化[J].解剖科学进展,2009,15(01):116-119.

[23]JiangJ,YamatoE,MiyazakiJ.IntravenousdeliveryofnakedplasmidDNAforinvivocytokineexpression[J].BiochemBiophysResCommun,2001,289(5):1088-1092.

[24]代雪枫,陈东风.非酒精性脂肪肝再生信号转导异常的研究进展[J].第三军医大学包,2019,22(27):2295-7.

[25]董爽,吴晨明,胡君伟,等.Wnt5a对人肝星状细胞促炎细胞因子IL-1β及IL-6表达的影响[J].中华微生物学和免疫学杂志,2014,34(1):332-445.

[26]ManiA,RadhakrishnanJ,WangH,etal.LRP6mutationinafamilywithearlycoronarydiseaseandmetabolicriskfactors[publishedcorrectionappearsinScience2013Aug30;341(6149):959][J].Science,2007(5816):1278-1282.

[27]VanCampJK,ZegersD,VerhulstSL,etal.MutationanalysisofWNT10Binobesechildren,adolescentsandadults[J].Endocrine,2013,44(1):107-113.

[28]BellLN,WangJ,MuralidharanS,etal.Relationshipbetweenadiposetissueinsulinresistanceandliverhistologyinnonalcoholicsteatohepatitis:apioglitazoneversusvitaminEversusplaceboforthetreatmentofnondiabeticpatientswithnonalcoholicsteatohepatitistrialfollow-upstudy[J].Hepatology,2012,56(4):1311-1318.


(95 摘要 Views, 60 PDF Downloads)

Refbacks

  • 当前没有refback。