血管纹对年龄相关性听力损失发病机制中的作用
摘要
vascularis，SV）是一种主要的耳蜗结构，可以独立退化并影响听力。本文旨在综述血管纹与年龄相关性听力损失关系的研
究进展，重点关注在不同病因下血管纹的功能障碍及所致年龄相关性听力损失的文献，这些病因包括氧化应激与炎症、线
粒体功能障碍、血管损伤、基因缺失等方面，尝试从细胞和分子生物学水平上探索其机制。
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[1] Wang J, Puel J L. Presbycusis: An Update on Cochlear
Mechanisms and Therapies [J]. J Clin Med, 2020, 9（1）.
[2] Liu H, Giffen K P, Chen L, et al. Molecular and
cytological profiling of biological aging of mouse cochlear inner
and outer hair cells [J]. Cell Rep, 2022, 39（2）: 110665.
[3] Bazard P, Frisina R D, Acosta A A, et al. Roles of Key
Ion Channels and Transport Proteins in Age-Related Hearing Loss
[J]. Int J Mol Sci, 2021, 22（11）.
[4] Spicer S S, Schulte B A. The fine structure of spiral
ligament cells relates to ion return to the stria and varies with
place-frequency [J]. Hear Res, 1996, 100（1-2）: 80-100.
[5] Neng L, Zhang J, Yang J, et al. Structural changes in
thestrial blood-labyrinth barrier of aged C57BL/6 mice [J]. Cell
Tissue Res, 2015, 361（3）: 685-96.
[6] Keithley E M. Pathology and mechanisms of cochlear
aging [J]. J Neurosci Res, 2020, 98（9）: 1674-1684.
[7] Lyu A R, Kim T H, Park S J, et al. Mitochondrial
Damage and Necroptosis in Aging Cochlea [J]. Int J Mol Sci, 2020,
21（7）.
[8] Peng Z, Zhao C, Yang Z, et al. D-galactose-induced
mitochondrial oxidative damage and apoptosis in the cochlear stria
vascularis of mice [J]. BMC Mol Cell Biol, 2023, 24（1）: 27.
[9] Yiming G, Fan W, Wuhui H, et al. ROS-related
disruptions to cochlear hair cell and stria vascularis consequently
leading to radiation-induced sensorineural hearing loss [J].
Antioxid Redox Signal, 2023.
[10] Keithley E M, Canto C, Zheng Q Y, et al. Cu/Zn
superoxide dismutase and age-related hearing loss [J]. Hear Res,
2005, 209（1-2）: 76-85.
[11] Zhang N, Cai J, Xu L, et al. Cisplatin-Induced Stria
Vascularis Damage Is Associated with Inflammation and Fibrosis
[J]. Neural Plast, 2020, 2020: 8851525.
[12] Laurell G, Ekborn A, Viberg A, et al. Effects of a single
high dose of cisplatin on the melanocytes of the stria vascularis in
the guinea pig [J]. Audiol Neurootol, 2007, 12（3）: 170-8.
[13] Steyger P S. Mechanisms of Aminoglycoside- and
Cisplatin-Induced Ototoxicity [J]. Am J Audiol, 2021, 30（3s）:
887-900.
[14] Han H W, Yee J, Park Y H, et al. Association between
Statin Use and Sensorineural Hearing Loss in Type 2 Diabetic
Patients: A Hospital-Based Study [J]. Pharmaceuticals （Basel）,
2021, 14（11）.
[15] Lee Y Y, Kim Y J, Gil E S, et al. Type 1 Diabetes
Induces Hearing Loss: Functional and Histological Findings in An
Akita Mouse Model [J]. Biomedicines, 2020, 8（9）.
[16] García Callejo F J, Orts Alborch M H, Morant Ventura
A, et al. [Neurosensory sudden deafness, blood hyperviscosity
syndrome, and diabetes mellitus] [J]. Acta Otorrinolaringol Esp,
2002, 53（3）: 221-4.
[17] Esse R, Barroso M, Tavares De Almeida I, et al.
The Contribution of Homocysteine Metabolism Disruption to
Endothelial Dysfunction: State-of-the-Art [J]. Int J Mol Sci, 2019,
20（4）.
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