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可注射透明质酸 / 海藻酸钠水凝胶修复耳软骨缺损的应用研究

元 红艳

摘要

目的 : 制备一种可注射水凝胶,并研究该水凝胶的理化性能及生物相容性。方法 : 以透明质酸和海藻酸钠为主要原
料加入氯化钙溶液后制备可注射水凝胶,通过流变学测试、凝胶时间测试和体外细胞实验对其流变学性能、溶胀和降解性
能进行表征,及细胞生物相容性分析。结果 :HA/SA(2%)水凝胶具有介于固态和液态之间的流变学特征,凝胶时间约为
3min,在 PBS 溶液中浸泡 30d 后质量损失率为 45wt.%。HA/SA(2%)水凝胶浸提液对细胞增殖无任何毒性,并促进了细胞增殖。
结论 :HA/SA(2%)水凝胶具有良好的可注射性、可降解性和生物相容性。

关键词

注射水凝胶;耳软骨缺损;修复;海藻酸钠

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参考

[1] M. de Boutray, A. Veyssiere, F. Bekara, and N. Graillon,

“Repair of gauge earlobe medium defect,” J. Stomatol. Oral.

Maxillofac. Surg., 2020, 121(4). 430–433,

[2] B. M. Hong, H. C. Kim, J. E. Jeong, S. A. Park, and W. H.

Park, “Visible-light-induced hyaluronate hydrogel for soft tissue

fillers,” Int. J.Biological Macromol., 2020, 165. 2834–2844.

[3] H. Park, B. Choi, J. Hu, and M. Lee, “Injectable chitosan

hyaluronic acid hydrogels for cartilage tissue engineering,” Acta

Biomater., 2013, 9(1).4779–4786.

[4] A. Marionneaux, J. Walters, H. Guo, and J. Mercuri,

“Tailoring the subchondral bone phase of a multi-layered

osteochondral construct to support bone healing and a cartilage

analog,” Acta Biomater., 2018, 78. 351–364.

[5] B. Kong et al., “Fiber reinforced GelMA hydrogel to

induce the regeneration of corneal stroma,” Nat Commun, 2020,

11(1).

[6] B. Niu et al., “In vitro and in vivo release of diclofenac

sodium-loaded sodium alginate/carboxymethyl chitosan-ZnO

hydrogel beads,” Int. J. Biological Macromol., 2019, 141. 1191–

1198.

[7] L. Chen et al., “Drug-Loadable Calcium Alginate

Hydrogel System for Use in Oral Bone Tissue Repair,” IJMS,

2017, 18(5). 989.

[8] N. L. D’Elía, C. Mathieu, C. D. Hoemann, J.

A. Laiuppa, G. E. Santillán, and P. V. Messina, “Bonerepair properties of biodegradable hydroxyapatite nano-rod

superstructures,” Nanoscale, 2015, 7(44). 18751–18762.

[9] Y. Yang, X. Wang, F. Yang, L. Wang, and D. Wu, “Highly

Elastic and Ultratough Hybrid Ionic-Covalent Hydrogels with

Tunable Structures and Mechanics,”Adv. Mater., 2018, 30(18).

1707071.


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