可注射透明质酸 / 海藻酸钠水凝胶修复耳软骨缺损的应用研究
摘要
料加入氯化钙溶液后制备可注射水凝胶,通过流变学测试、凝胶时间测试和体外细胞实验对其流变学性能、溶胀和降解性
能进行表征,及细胞生物相容性分析。结果 :HA/SA(2%)水凝胶具有介于固态和液态之间的流变学特征,凝胶时间约为
3min,在 PBS 溶液中浸泡 30d 后质量损失率为 45wt.%。HA/SA(2%)水凝胶浸提液对细胞增殖无任何毒性,并促进了细胞增殖。
结论 :HA/SA(2%)水凝胶具有良好的可注射性、可降解性和生物相容性。
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