可注射透明质酸 / 海藻酸钠水凝胶修复耳软骨缺损的应用研究
摘要
料加入氯化钙溶液后制备可注射水凝胶，通过流变学测试、凝胶时间测试和体外细胞实验对其流变学性能、溶胀和降解性
能进行表征，及细胞生物相容性分析。结果 :HA/SA（2%）水凝胶具有介于固态和液态之间的流变学特征，凝胶时间约为
3min，在 PBS 溶液中浸泡 30d 后质量损失率为 45wt.%。HA/SA（2%）水凝胶浸提液对细胞增殖无任何毒性，并促进了细胞增殖。
结论 :HA/SA（2%）水凝胶具有良好的可注射性、可降解性和生物相容性。
关键词
全文:
PDF参考
[1] M. de Boutray, A. Veyssiere, F. Bekara, and N. Graillon,
“Repair of gauge earlobe medium defect,” J. Stomatol. Oral.
Maxillofac. Surg., 2020, 121（4）. 430–433,
[2] B. M. Hong, H. C. Kim, J. E. Jeong, S. A. Park, and W. H.
Park, “Visible-light-induced hyaluronate hydrogel for soft tissue
fillers,” Int. J.Biological Macromol., 2020, 165. 2834–2844.
[3] H. Park, B. Choi, J. Hu, and M. Lee, “Injectable chitosan
hyaluronic acid hydrogels for cartilage tissue engineering,” Acta
Biomater., 2013, 9（1）.4779–4786.
[4] A. Marionneaux, J. Walters, H. Guo, and J. Mercuri,
“Tailoring the subchondral bone phase of a multi-layered
osteochondral construct to support bone healing and a cartilage
analog,” Acta Biomater., 2018, 78. 351–364.
[5] B. Kong et al., “Fiber reinforced GelMA hydrogel to
induce the regeneration of corneal stroma,” Nat Commun, 2020,
11（1）.
[6] B. Niu et al., “In vitro and in vivo release of diclofenac
sodium-loaded sodium alginate/carboxymethyl chitosan-ZnO
hydrogel beads,” Int. J. Biological Macromol., 2019, 141. 1191–
1198.
[7] L. Chen et al., “Drug-Loadable Calcium Alginate
Hydrogel System for Use in Oral Bone Tissue Repair,” IJMS,
2017, 18（5）. 989.
[8] N. L. D’Elía, C. Mathieu, C. D. Hoemann, J.
A. Laiuppa, G. E. Santillán, and P. V. Messina, “Bonerepair properties of biodegradable hydroxyapatite nano-rod
superstructures,” Nanoscale, 2015, 7（44）. 18751–18762.
[9] Y. Yang, X. Wang, F. Yang, L. Wang, and D. Wu, “Highly
Elastic and Ultratough Hybrid Ionic-Covalent Hydrogels with
Tunable Structures and Mechanics,”Adv. Mater., 2018, 30（18）.
1707071.
(31 摘要 Views, 312 PDF Downloads)
Refbacks
- 当前没有refback。