光控水凝胶负载太子参多糖对大鼠糖尿病溃疡创面修复作用研究
摘要
溃疡创面修复效果。方法 : 以 PolyCBNA 和明胶为主要原料制备光控水凝胶，通过微观结构、药物释放量和体内动物实验
对其进行分析评估。结果 : PolyCBNA/ 明胶 / 太子参多糖结构更紧密，说明，加入太子参多糖后，能改变水凝胶的微观结构。
而 24 时，太子参多糖的释放量达到 47%。动物模型修复效果更证实表明负载太子参多糖的水凝胶有效促进伤口愈合。结论 :
PolyCBNA/ 明胶 / 太子参多糖具有良好的光控性、释药性和修复效果。
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[1] Tu, C.；Lu, H.；Zhou, T.；Zhang, W.；Deng, L.；
Cao, W.；Yang, Z.；Wang, Z.；Wu, X.；Ding, J.；Xu, F.；
Gao, C. Promoting the Healing of Infected Diabetic Wound by
an Anti-Bacterial and Nano-Enzyme-Containing Hydrogel with
Inflammation-Suppressing, ROS-Scavenging, Oxygen and Nitric
Oxide-Generating Properties. Biomaterials 2022, 286, 121597.
https://doi.org/10.1016/j.biomaterials.2022.121597.
[2] Guan, Y.；Niu, H.；Liu, Z.；Dang, Y.；Shen, J.；Zayed, M.；
Ma, L.；Guan, J. Sustained Oxygenation Accelerates Diabetic
Wound Healing by Promoting Epithelialization and Angiogenesis
and Decreasing Inflammation.Sci.Adv.2021,7（35）.https://doi.
org/10.1126/sciadv.abj0153.
[3] Wang, M.；Du, J.；Li, M.；Pierini, F.；Li, X.；Yu,
J.；Ding, B. In Situ Forming Double-Crosslinked Hydrogels
with Highly Dispersed Short Fibers for the Treatment of Irregular
Wounds. Biomater. Sci. 2023, 11 （7）, 2383–2394. https://doi.
org/10.1039/d2bm01891h.
[4] Ahmed, T. A. E.；Suso, H.-P.；Maqbool, A.；Hincke,
M. T. Processed Eggshell Membrane Powder: Bioinspiration for an
Innovative Wound Healing Product. Mater. Sci. Eng. C 2019, 95,
192–203. https://doi.org/10.1016/j.msec.2018.10.054.
[5] Dong, R.；Li, Y.；Chen, M.；Xiao, P.；Wu, Y.；Zhou, K.；
Zhao, Z.；Tang, B. Z. In Situ Electrospinning of Aggregation‐
Induced Emission Nanofibrous Dressing for Wound Healing.
Small Method 2022, 6 （5）, 2101247. https://doi.org/10.1002/
smtd.202101247.
[6] Li, X.；Ma, M.；Ahn, D. U.；Huang, X. Preparation
and Characterization of Novel Eggshell Membrane-Chitosan
Blend Films for Potential Wound-Care Dressing: From Waste to
Medicinal Products. Int. J. Biological Macromol. 2019, 123, 477–
484. https://doi.org/10.1016/j.ijbiomac.2018.10.215.
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