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血液透析对终末期肾脏病患者红细胞免疫功能的影响

宋 仕华, 韩 帅, 高 弼虎

摘要

目的:探究血液透析对终末期肾脏病患者红细胞免疫功能的影响。方法:选取大连大学附属中山医院血液净化中心的血液透析患者57例(血液透析组)、该院终末期肾脏病未进行血液透析患者57例(终末期肾脏病组)以及该院体检中心的健康人53例(对照组)。用全自动血液检测仪检测血红蛋白和红细胞计数,用郭峰法测定所各组的红细胞C3b受体花环率(RBC-C3bRR)、红细胞免疫复合物花环率(RBC-ICR)、红细胞免疫促进因子(RFER)、红细胞免疫抑制因子(RFIR)变化,用流式细胞术测定各组的CD58、CD59变化,收集患者一般资料。结果:与对照组和终末期肾脏病组相比,血液透析组的血红蛋白和红细胞计数显著减少(p<0.05),RBC-C3bRR和RFER 明显降低(p<0.05),而RBC-ICR 和RFIR明显升高(p<0.05),此外,血液透析组的CD58、CD59也明显降低(p<0.05)。结论:在终末期肾脏病中,血液透析会降低患者的红细胞免疫功能。

关键词

终末期肾脏病;血液透析;红细胞免疫

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参考

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