开放期刊系统

胃癌血清学肿瘤标志物国内外研究新进展

杨 健华, 朱 艳丽, 李 姣姣, 陈 怡

摘要

胃癌是全球第四大常见恶性疾病之一,也是全球第二大癌症相关死亡原因,由于其发病隐匿往往诊断即晚期预后不理想,因此采用有效的筛查方法进行早期发现对于降低胃癌死亡率非常重要。近年来,肿瘤标志物这种非侵入的检测方式受到广泛关注,本文将对胃癌血清学标志物作以综述,以期为胃癌患者的诊断和监测开辟了新的机会。

关键词

胃癌;血清学检测;肿瘤标志物;

全文:

PDF

参考

[1]Alsina M,Arrazubi V,Diez M,Tabernero J. Current developments in gastric cancer:from molecular profiling to treatment strategy. Nat Rev Gastroenterol Hepatol. 2023 Mar;20(3):155-170. doi:10.1038/s41575-022-00703-w. Epub 2022 Nov 7. PMID:36344677。 [2]Giuppi M,La Salvia A,Evangelista J,Ghidini M. The Role and Expression of Angiogenesis-Related miRNAs in Gastric Cancer. Biology(Basel). 2021 Feb 12;10(2):146. doi:10.3390/biology10020146. PMID:33673057;PMCID:PMC7918665. [3]Malhone C,Longatto-Filho A. Cervical,Ovarian and Endometrial Tumor Markers:Potential Clinical Value. Semin Ultrasound CT MR. 2019 Aug;40(4):350-357. doi:10.1053/j.sult.2019.03.003. Epub 2019 Mar 5. PMID:31375174. [4]Konstantopoulos K,Thomas SN. Cancer cells in transit:the vascular interactions of tumor cells. Annu Rev Biomed Eng. 2009;11:177-202. doi:10.1146/annurev-bioeng-061008-124949. PMID:19413512. [5]Culcu S,Yuksel C,Aydin F,Bakirarar B,Aksel B,Dogan L. The effect of CEA/Albumin ratio in gastric cancer patient on prognostic factors. Ann Ital Chir. 2022;93:447-452. PMID:36155996. [6]杜后英.血清 miR-144、CEA、CA724 及 CA125 联合检测对早期胃癌的诊断价值[J].实用癌症杂志,2022,37(12):2016-2019+2035. [7]Li X,Li S,Zhang Z,Huang D. Association of multiple tumor markers with newly diagnosed gastric cancer patients:a retrospective study. PeerJ. 2022 May 19;10:e13488. doi:10.7717/peerj.13488. PMID:35611170;PMCID:PMC9124459. [8]Park JH,et al. Diagnostic performance of serum CA19-9 and CA242 for pancreatic cancer:a meta-analysis. Gastrointest Endosc. 2015;82(4):688-697.e1. [9]宋诗. Tspan9 及 CEA、CA199、CA724、CA242 作为进展期胃癌新辅助化疗敏感性指标的研究[D].青岛大学,2020.DOI:10.27262/d.cnki.gqdau.2020.000041. [10]莫堂明.胃癌诊断中联合检测胃泌素-17、CEA、CA199 及 CA125 的临床应用价值[D].广西医科大学,2020.DOI:10.27038/d.cnki.ggxyu.2020.000444. [11]Luo G,Jin K,Deng S,Cheng H,Fan Z,Gong Y,Qian Y,Huang Q,Ni Q,Liu C,Yu X. Roles of CA19-9 in pancreatic cancer : Biomarker , predictor and promoter. Biochim Biophys Acta Rev Cancer. 2021 Apr ; 1875 ( 2 ): 188409. doi :10.1016/j.bbcan.2020.188409. Epub 2020 Aug 19. PMID:32827580. [12]李美霞,李红利,常建兰.VEGF 和 NPR3 在胃癌中的作用机制研究进展[J].长治医学院学报,2023,37(01):65-68. [13]Mizutani Y,Kobayashi T,Ishikawa T,et al. Clinical significance of vascular endothelial growth factor-C and -D expression in gastric adenocarcinoma. Oncol Lett. 2018;15(2):2099-2106. [14]王锐,吴娜,陈文婷,彭昭,孙剑经,高会斌,宋征宇.GOLPH3、VEGF 在胃癌组织中的表达情况及其临床意义[J].中国实验诊断学,2022,26(09):1265-1268.


(6 摘要 Views, 5 PDF Downloads)

Refbacks

  • 当前没有refback。