开放期刊系统

免疫检查点抑制剂相关肺炎的早期识别与糖皮质激素治疗策略

韩 进, 孙红 花*

摘要

免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)显著改善了多种晚期恶性肿瘤患者的预后,但同时也引发了以
肺炎为代表的免疫相关不良事件(immune-related adverse events,irAEs)。其中,免疫检查点抑制剂相关肺炎(checkpoint
inhibitor-related pneumonitis,CIP)具有较高的潜在致死风险,已成为临床管理的难点与重点。CIP起病隐匿,临床症状
缺乏特异性,易被误诊为感染或肿瘤进展,常导致治疗延误、预后不良。规范的早期识别、分级评估以及糖皮质激素治
疗,对于改善患者结局至关重要。本文系统梳理CIP的发病机制、临床表现、辅助检查、诊断流程及激素治疗策略,旨
在为临床实践提供科学、可操作的诊疗依据。

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