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探讨 SIAH1 的表达对口腔鳞状细胞癌生物学行为的影响

晏 雪迪, 姜 春善

摘要

口腔鳞状细胞癌(OSCC)是头颈部恶性肿瘤中最具侵袭性的类型之一,其高复发率与治疗耐药性亟需新的分子靶点。SIAH1作为E3泛素连接酶,通过泛素-蛋白酶体系统动态调控AKT/YAP、HIF-1α及Wnt/β-catenin等信号通路,在多种癌症中呈现促癌或抑癌的双重功能。本文综述SIAH1的分子机制及其在OSCC中的潜在作用,提出其在OSCC低氧微环境、TP53突变及HPV感染背景下的调控假说:SIAH1可能通过稳定HIF-1α增强肿瘤代谢适应、降解p27促进细胞周期失调,或协同HPV癌蛋白加剧抑癌蛋白失活。进一步探讨靶向SIAH1的治疗策略,包括小分子激动剂/抑制剂开发、联合低氧或免疫疗法,以及基于基因编辑的精准干预。然而,SIAH1功能的组织特异性与泛素化网络复杂性要求未来研究需构建OSCC特异性模型,并开发伴随诊断工具以指导个体化治疗。本文为理解SIAH1在OSCC中的生物学意义及临床转化提供了系统性视角。

关键词

SIAH1;口腔鳞状细胞癌;泛素-蛋白酶体系统;HIF-1α信号通路;靶向治疗;肿瘤微环境

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参考

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