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溶瘤病毒在肝细胞癌治疗中的研究现状及前景

郝 俊杰, 丛 美玉, 孙 红花

摘要

溶瘤病毒(OVs)在癌症治疗中展现出巨大的潜力,尤其是在多模式治疗策略中。尽管现有的临床试验表明OV治疗相对安全且不良反应较少,但在肝癌治疗方面,OV的临床应用仍面临显著挑战,尤其是在从前临床研究到临床验证的转化过程中。未来的研究应集中于优化OV的治疗效果,探索不同类型和修饰的OVs,以提高其在肝癌中的疗效。为了验证OVs作为有效治疗选择的潜力,开展大规模的临床试验至关重要。此外,尽管OVs的安全性令人鼓舞,但需要注意样本量和患者选择的局限性。因此,弥合基础科学与临床应用之间的差距是实现OVs在肝癌患者中成功应用的关键。

关键词

溶瘤病毒肝细胞癌溶瘤病毒疗法

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